Evidence map›Paper›PMID 33240275›Full record

ArticleFrontiers in immunology2020

Rescuing ESAT-6 Specific CD4 T Cells From Terminal Differentiation Is Critical for Long-Term Control of Murine Mtb Infection.

Helena Strand Clemmensen, Niels Peter Hell Knudsen, Rolf Billeskov, Ida Rosenkrands, Gregers Jungersen, Claus Aagaard, Peter Andersen, Rasmus Mortensen

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.3field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

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  15. Article
  16. mBio · 2021
    Article
  17. Review
  18. Advancing Adjuvants forFrontiers in immunology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Helena Strand ClemmensenDepartment of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark.
Niels Peter Hell KnudsenDepartment of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark.
Rolf BilleskovDepartment of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark.
Ida RosenkrandsDepartment of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark.
Gregers JungersenDepartment of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark.
Claus AagaardDepartment of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark.
Peter AndersenDepartment of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark.
Rasmus MortensenDepartment of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark.
Statens Serum Institut · DKTechnical University of Denmark · DKUniversity of Copenhagen · DK

Funding

A dual function TB subunit vaccine designed for non-interference with BCG and post-exposure activityR01AI135721 · NIAID · STATENS SERUM INSTITUTE · PI MORTENSEN, RASMUS SKAARUP · 2018 to 2022
$3.5M
NIAID NIH HHS R01 AI135721
6 · The paper itself

Abstract

In most cases,

Indexed as

AnimalsAntigens, BacterialBacterial ProteinsCD4-Positive T-LymphocytesCell DifferentiationFemaleImmunodominant EpitopesLymphocyte ActivationMiceMycobacterium tuberculosisTuberculosisTuberculosis VaccinesVaccines, SubunitAntigens, BacterialBacterial ProteinsESAT-6 protein, Mycobacterium tuberculosisImmunodominant EpitopesTuberculosis VaccinesVaccines, SubunitESAT-6immunodominant antigenslong-term protectionmouse modelsMycobacterium tuberculosisT cell differentiationtuberculosisvaccines

Identifiers

PMID33240275
PMCPMC7677256
OpenAlexW3096561986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.