Evidence map›Paper›PMID 33240263›Full record

ArticleFrontiers in immunology2020

The Role of Properdin in Killing of Non-Pathogenic

Adriana Patricia Granados Martinez, Patrícia Antonia Estima Abreu, Silvio de Arruda Vasconcellos, Paulo Lee Ho, Viviana P Ferreira, Gurpanna Saggu, Angela Silva Barbosa, Lourdes Isaac

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Adriana Patricia Granados MartinezDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Patrícia Antonia Estima AbreuLaboratory of Bacteriology, Butantan Institute, São Paulo, Brazil.
Silvio de Arruda VasconcellosLaboratory of Bacterial Zoonoses, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.
Paulo Lee HoLaboratory of Bacteriology, Butantan Institute, São Paulo, Brazil.
Viviana P FerreiraDepartment of Medical Microbiology and Immunology, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, United States.
Gurpanna SagguDepartment of Medical Microbiology and Immunology, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, United States.
Angela Silva BarbosaLaboratory of Bacteriology, Butantan Institute, São Paulo, Brazil.
Lourdes IsaacDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Instituto Butantan · BRUniversidade de São Paulo · BRUniversity of Toledo Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Properdin (P) is a positive regulatory protein that stabilizes the C3 convertase and C5 convertase of the complement alternative pathway (AP). Several studies have suggested that properdin can bind directly to the surface of certain pathogens regardless of the presence of C3bBb. Saprophytic

Indexed as

Bacterial Outer Membrane ProteinsCell Growth ProcessesComplement C3bComplement Factor BComplement Pathway, AlternativeCytotoxicity, ImmunologicHumansLeptospiraLeptospira interrogansLeptospirosisProperdinProtein BindingVirulenceBacterial Outer Membrane ProteinsComplement C3bComplement Factor BProperdinalternative pathwaybacteria killing abilitycomplement systemLeptospiraproperdin

Identifiers

PMID33240263
PMCPMC7683387
OpenAlexW3100445565

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.