Evidence map›Paper›PMID 33240251›Full record

ArticleFrontiers in microbiology2020

Pulse Dosing of Antibiotic Enhances Killing of a

Kirsten J Meyer, Hannah B Taylor, Jazlyn Seidel, Michael F Gates, Kim Lewis

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kirsten J MeyerDepartment of Biology, Antimicrobial Discovery Center, Northeastern University, Boston, MA, United States.
Hannah B TaylorDepartment of Biology, Antimicrobial Discovery Center, Northeastern University, Boston, MA, United States.
Jazlyn SeidelDepartment of Biology, Antimicrobial Discovery Center, Northeastern University, Boston, MA, United States.
Michael F GatesDepartment of Biology, Antimicrobial Discovery Center, Northeastern University, Boston, MA, United States.
Kim LewisDepartment of Biology, Antimicrobial Discovery Center, Northeastern University, Boston, MA, United States.

Funding

A general mechanism of persister formationR01AI141966 · NIAID · NORTHEASTERN UNIVERSITY · PI LEWIS, KIM, PAULSSON, JOHAN · 2019 to 2022
$2.9M
6 · The paper itself

Abstract

Biofilms are highly tolerant to antibiotics and underlie the recalcitrance of many chronic infections. We demonstrate that mature

Indexed as

antibiotic tolerancebiofilm treatmentintermittent dosingoxacillinperiodic dosingpersister resuscitationpulse dosingStaphylococcus aureus

Identifiers

PMID33240251
PMCPMC7680849

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.