Evidence map›Paper›PMID 33240156›Full record

ArticleFrontiers in psychology2020

Lower Cardiac Output Relates to Longitudinal Cognitive Decline in Aging Adults.

Corey W Bown, Rachel Do, Omair A Khan, Dandan Liu, Francis E Cambronero, Elizabeth E Moore, Katie E Osborn, Deepak K Gupta, Kimberly R Pechman, Lisa A Mendes and 3 more

Abstract read
In one paragraph

Article in Frontiers in psychology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. A cardiovascular-motor axis framework for perfusion-mediated motor impairment.International journal of cardiology. Heart & vasculature · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Relationship between cardiac index and brain volume in the UK Biobank.Cerebral circulation - cognition and behavior · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Observational
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Corey W BownVanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.
Rachel DoVanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.
Omair A KhanVanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.
Dandan LiuVanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.
Francis E CambroneroVanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.
Elizabeth E MooreVanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.
Katie E OsbornVanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.
Deepak K GuptaDivision of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Kimberly R PechmanVanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.
Lisa A MendesDivision of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Timothy J HohmanVanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.
Katherine A GiffordVanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.
Angela L JeffersonVanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
Vanderbilt Memory & Aging ProjectR01AG034962 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JEFFERSON, ANGELA L. · 2011 to 2025
$24.1M
Medical Scientist Training ProgramT32GM152284 · NIGMS · VANDERBILT UNIVERSITY · PI Christopher S. Williams · 2024 to 2026
$4.8M
Vanderbilt Interdisciplinary Training Program in Alzheimer's DiseaseT32AG058524 · NIA · VANDERBILT UNIVERSITY · PI ANGELA L. JEFFERSON · 2018 to 2026
$3.5M
White matter and small vessel disease in older adultsR01AG056534 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JEFFERSON, ANGELA L. · 2017 to 2021
$3.2M
Cardiovascular predictors of cerebrovascular health in older adultsR01NS100980 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JEFFERSON, ANGELA L. · 2017 to 2021
$3.0M
Vascular Factors Underlying Abnormal Cognitive AgingR01HL111516 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JEFFERSON, ANGELA L. · 2012 to 2017
$1.9M
Risk factors and prevention targets for abnormal cognitive agingK24AG046373 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JEFFERSON, ANGELA L. · 2014 to 2023
$1.7M
Cognitive Complaints in Aging AdultsK23AG045966 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GIFFORD, KATHERINE A. · 2015 to 2022
$960k
Genetic Resilience to the Clinical Manifestation of DementiaK01AG049164 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HOHMAN, TIMOTHY J · 2016 to 2020
$595k
High-Performance Computer Cluster for Biomedical ResearchS10OD023680 · OD · VANDERBILT UNIVERSITY · PI MEILER, JENS · 2017 to 2017
$587k
NCATS NIH HHS UL1 TR000445NHLBI NIH HHS R01 HL111516NIA NIH HHS F30 AG064847NIA NIH HHS F31 AG059345NIA NIH HHS F31 AG066358NIA NIH HHS F32 AG058395NIA NIH HHS K01 AG049164NIA NIH HHS K23 AG045966NIA NIH HHS K24 AG046373NIA NIH HHS R01 AG034962NIA NIH HHS R01 AG056534NIA NIH HHS T32 AG058524NIGMS NIH HHS T32 GM007347NIGMS NIH HHS T32 GM152284NIH HHS S10 OD023680NINDS NIH HHS R01 NS100980
6 · The paper itself

Abstract

backgroundSubclinical reductions in cardiac output correspond to lower cerebral blood flow (CBF), placing the brain at risk for functional changes.

objectivesThis study aims to establish the consequences of reduced cardiac output on longitudinal cognitive outcomes in aging adults.

methodsVanderbilt Memory and Aging Project participants free of clinical dementia and heart failure (

resultsLower baseline cardiac output related to faster declines in language (β = 0.11,

conclusionThe present study provides evidence that even subtle reductions in cardiac output may be associated with more adverse longitudinal cognitive health, including worse language, information processing speed, visuospatial skills, and episodic memory performances. Preservation of healthy cardiac functioning is important for maintaining optimal brain aging among older adults.

Indexed as

agingapolipoprotein E ε4cardiac functioncognitive declinemild cognitive impairment

Identifiers

PMID33240156
PMCPMC7680861

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.