Evidence map›Paper›PMID 33240074›Full record

ArticleFrontiers in aging neuroscience2020

Interaction of Age and Self-reported Physical Sports Activity on White Matter Hyperintensity Volume in Healthy Older Adults.

Mary Kathryn Franchetti, Pradyumna K Bharadwaj, Lauren A Nguyen, Emily J Van Etten, Yann C Klimentidis, Georg A Hishaw, Theodore P Trouard, David A Raichlen, Gene E Alexander

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Associations of sleep behaviors with white matter hyperintensity volume in middle-aged to older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Mary Kathryn FranchettiDepartment of Psychology, University of Arizona, Tucson, AZ, United States.
Pradyumna K BharadwajDepartment of Psychology, University of Arizona, Tucson, AZ, United States.
Lauren A NguyenDepartment of Psychology, University of Arizona, Tucson, AZ, United States.
Emily J Van EttenDepartment of Psychology, University of Arizona, Tucson, AZ, United States.
Yann C KlimentidisDepartment of Epidemiology and Biostatistics, University of Arizona, Tucson, AZ, United States.
Georg A HishawDepartment of Neurology, University of Arizona, Tucson, AZ, United States.
Theodore P TrouardEvelyn F. McKnight Brain Institute, Tucson, AZ, United States.
David A RaichlenHuman and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, United States.
Gene E AlexanderDepartment of Psychology, University of Arizona, Tucson, AZ, United States.
University of Arizona · USArizona Alzheimer’s ConsortiumAlzheimer's Association · USUniversity of Southern California · US

Funding

Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI GONZALEZ HERNANDEZ, GRACIELA · 2001 to 2020
$32.5M
Epigenetic, Neuroimaging & Behavioral Effects of Hypertension in the Aging BrainR01AG049464 · NIA · UNIVERSITY OF ARIZONA · PI ALEXANDER, GENE E, BARNES, CAROL A. · 2014 to 2018
$2.4M
Neuroanatomical Substrates of Aging & Cognitive DeclineR01AG025526 · NIA · UNIVERSITY OF ARIZONA · PI ALEXANDER, GENE E · 2006 to 2010
$2.2M
Physical activity predictors of cognitive and brain health in the risk for Alzheimer's diseaseR56AG067200 · NIA · UNIVERSITY OF ARIZONA · PI ALEXANDER, GENE E, RAICHLEN, DAVID · 2020 to 2020
$767k
NIA NIH HHS P30 AG019610NIA NIH HHS R01 AG025526NIA NIH HHS R01 AG049464NIA NIH HHS R56 AG067200
6 · The paper itself

Abstract

Cerebral white matter (WM) lesion load, as measured by white matter hyperintensity (WMH) volume with magnetic resonance imaging (MRI), has been associated with increasing age and cardiovascular risk factors, like hypertension. Physical sports activity (PSA) may play an important role in maintaining WM in the context of healthy aging. In 196 healthy older adults, we investigated whether participants reporting high levels of PSA (

Indexed as

healthy agingmoderate to vigorous physical activity (MVPA)MRIphysical activity (exercise)regional white matter lesion loadwhite matter hyperintensity volumewhite matter (WM)

Identifiers

PMID33240074
PMCPMC7667263
OpenAlexW3095974189

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.