Evidence map›Paper›PMID 33239904›Full record

ArticleJournal of pain research2020

Preoperative Factors Associated with Remote Postoperative Pain Resolution and Opioid Cessation in a Mixed Surgical Cohort: Post Hoc Analysis of a Perioperative Gabapentin Trial.

Jennifer M Hah, Heather Hilmoe, Peter Schmidt, Rebecca McCue, Jodie Trafton, Debra Clay, Yasamin Sharifzadeh, Gabriela Ruchelli, Tina Hernandez Boussard, Stuart Goodman and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pain research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Jennifer M HahDivision of Pain Medicine, Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0002-9739-3968
Heather HilmoeStanford Systems Neuroscience and Pain Lab, Stanford University, Stanford, CA, USA.
Peter SchmidtStanford Systems Neuroscience and Pain Lab, Stanford University, Stanford, CA, USA.
Rebecca McCueStanford Systems Neuroscience and Pain Lab, Stanford University, Stanford, CA, USA.
Jodie TraftonDepartment of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA.
Debra ClayStanford Systems Neuroscience and Pain Lab, Stanford University, Stanford, CA, USA.
Yasamin SharifzadehStanford Systems Neuroscience and Pain Lab, Stanford University, Stanford, CA, USA.ORCID 0000-0003-3269-3107
Gabriela RuchelliStanford Systems Neuroscience and Pain Lab, Stanford University, Stanford, CA, USA.
Tina Hernandez BoussardDepartment of Medicine, Department of Biomedical Data Science, Stanford University, Stanford, CA, USA.ORCID 0000-0001-6553-3455
Stuart GoodmanDepartment of Orthopaedic Surgery and (by Courtesy) Bioengineering, Department of Orthopaedic Surgery, Stanford University, Stanford, CA, USA.ORCID 0000-0002-1919-3717
James HuddlestonDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA, USA.
William J MaloneyDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA, USA.
Frederick M DirbasDepartment of General Surgery, Stanford University, Stanford, CA, USA.ORCID 0000-0003-3576-6404
Joseph ShragerDivision of Thoracic Surgery, Stanford University, Stanford, CA, USA.
John G CostourosDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA, USA.
Catherine CurtinDivision of Hand and Plastic Surgery, Department of Orthopaedic Surgery, Stanford University, Stanford, CA, USA.ORCID 0000-0003-0850-9277
Sean C MackeyDivision of Pain Medicine, Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0001-7744-5348
Ian CarrollDivision of Pain Medicine, Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0002-4777-4834
Stanford University · USStanford Medicine · US

Funding

Psychological Risk Factors for Persistent Opioid Use and Prevention of Chronic Opioid Use and Misuse After Surgery: Postoperative Motivational Interviewing and Guided Opioid WeaningR01DA045027 · NIDA · STANFORD UNIVERSITY · PI HAH, JENNIFER · 2018 to 2022
$2.6M
Neuroimaging and Mentoring in Translational Pain ResearchK24DA029262 · NIDA · STANFORD UNIVERSITY · PI MACKEY, SEAN C · 2010 to 2019
$1.9M
NIDA NIH HHS K24 DA029262NIDA NIH HHS R01 DA045027
6 · The paper itself

Abstract

backgroundPreoperative patient-specific risk factors may elucidate the mechanisms leading to the persistence of pain and opioid use after surgery. This study aimed to determine whether similar or discordant preoperative factors were associated with the duration of postoperative pain and opioid use.

methodsIn this post hoc analysis of a randomized, double-blind, placebo-controlled trial of perioperative gabapentin vs active placebo, 410 patients aged 18-75 years, undergoing diverse operations underwent preoperative assessments of pain, opioid use, substance use, and psychosocial variables. After surgery, a modified Brief Pain Inventory was administered over the phone daily up to 3 months, weekly up to 6 months, and monthly up to 2 years after surgery. Pain and opioid cessation were defined as the first of 5 consecutive days of 0 out of 10 pain or no opioid use, respectively.

resultsOverall, 36.1%, 19.8%, and 9.5% of patients continued to report pain, and 9.5%, 2.4%, and 1.7% reported continued opioid use at 3, 6, and 12 months after surgery. Preoperative pain at the future surgical site (every 1-point increase in the Numeric Pain Rating Scale; HR 0.93; 95% CI 0.87-1.00;

conclusionSeparate risk factors for prolonged post-surgical pain and opioid use indicate that preoperative risk stratification for each outcome may identify patients needing personalized care to augment universal protocols for perioperative pain management and conservative opioid prescribing to improve long-term outcomes.

Indexed as

chronic opioid use after surgerychronic pain after surgerypersistent postoperative opioid usepersistent postsurgical pain

Identifiers

PMID33239904
PMCPMC7680674
OpenAlexW3100877904

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.