SynthesisCommunications biology2020
Large genome-wide association study identifies three novel risk variants for restless legs syndrome.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 6 pooled it
5.2field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 6 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Smoking and risk of restless leg syndrome: a systematic review, meta-analysis, and Mendelian randomisation.Journal of global health · 2026Pooled it
- Genomic Analysis Identifies Risk Factors in Restless Legs Syndrome.Annals of neurology · 2024Pooled it
- Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction.Nature genetics · 2024Pooled it
- Genome-wide study of longitudinal brain imaging measures of multiple sclerosis progression across six clinical trials.Scientific reports · 2023Pooled it
- Pooled it
- Putative Animal Models of Restless Legs Syndrome: A Systematic Review and Evaluation of Their Face and Construct Validity.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Pooled it
- Phenotype Refinement Influences GWAS-Implicated Variant Effect Sizes for Insomnia.Journal of sleep research · 2026Article
- Serum Concentrations of Cytokines in Patients With Restless Legs Syndrome.Journal of sleep research · 2026Article
- Polygenic risk scores in neurological disorders: restless legs syndrome as a translational model.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2026Article
- Integration of Brain Proteomes and Genome-Wide Association Data Identifies GLO1 as a Candidate Causal Gene and Therapeutic Target for Restless Legs Syndrome.International journal of molecular sciences · 2026Article
- Ancestry-specific and multi-ancestry genome-wide association studies of restless legs syndrome.medRxiv : the preprint server for health sciences · 2026Article
- Sleep Related Movement Disorders: What's New and Changing Clinical Practice.Journal of sleep research · 2025Review
- Synaptic and Non-Synaptic Functions of PTPRD: A Receptor Tyrosine Phosphatase at the Crossroads of Neural Circuitry and Metabolism.Journal of neurochemistry · 2025Review
- Genomic diversity in Chinese Holstein cattle and genome-wide association study for body conformation traits.BMC genomics · 2025Article
- Article
- Genome-wide association analysis of composite sleep health scores in 413,904 individuals.Communications biology · 2025Article
- Transcriptomic Changes and Pathological Mechanisms in Familial and Sporadic Idiopathic Restless Legs Syndrome: Implications for Inflammation and Cell Adhesion Molecules.Nature and science of sleep · 2025Article
- Identification of Causal Genes and Potential Drug Targets for Restless Legs Syndrome: A Comprehensive Mendelian Randomization Study.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Perceptions of exercise and restless legs syndrome: Results from a nationwide survey.Journal of sleep research · 2024Article
- Proteomic insights into the pathophysiology of periodic limb movements and restless legs syndrome.Sleep health · 2024Article
Corrections and comments
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Authors and funding
34 authors at 14 institutions in 6 countries.
Maria DidriksenDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, 2100, Copenhagen, Denmark.ORCID 0000-0002-4856-496X
Muhammad Sulaman NawazdeCODE Genetics, 101, Reykjavik, Iceland.ORCID 0000-0002-5576-9007
Joseph DowsettDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, 2100, Copenhagen, Denmark.ORCID 0000-0001-5381-2633
Steven BellThe National Institute for Health Research Blood and Transplant Unit in Donor Health and Genomics, University of Cambridge, Cambridge, CB1 8RN, UK.ORCID 0000-0001-6774-3149
Christian ErikstrupDepartment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0001-6551-6647
Ole B PedersenDepartment of Clinical Immunology, Nastved Sygehus, Nastved, Denmark.ORCID 0000-0003-2312-5976
Erik SørensenDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, 2100, Copenhagen, Denmark.
Poul J JennumDepartment of Clinical Neurophysiology, Danish Center for Sleep Medicine, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark.
Kristoffer S BurgdorfDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, 2100, Copenhagen, Denmark.
Brendan BurchellFaculty of Human, Social and Political Sciences, University of Cambridge, Cambridge, CB1 8RN, UK.ORCID 0000-0002-8243-937X
Adam S ButterworthThe National Institute for Health Research Blood and Transplant Unit in Donor Health and Genomics, University of Cambridge, Cambridge, CB1 8RN, UK.ORCID 0000-0002-6915-9015
Nicole SoranzoThe National Institute for Health Research Blood and Transplant Unit in Donor Health and Genomics, University of Cambridge, Cambridge, CB1 8RN, UK.
David B RyeDepartment of Neurology and Program in Sleep, Emory University, Atlanta, GA, USA.
Lynn Marie TrottiDepartment of Neurology and Program in Sleep, Emory University, Atlanta, GA, USA.
Prabhjyot SainiDepartment of Neurology and Program in Sleep, Emory University, Atlanta, GA, USA.
Lilja StefansdottirdeCODE Genetics, 101, Reykjavik, Iceland.
Sigurdur H MagnussondeCODE Genetics, 101, Reykjavik, Iceland.
Gudmar ThorleifssondeCODE Genetics, 101, Reykjavik, Iceland.
Thordur SigmundssonFaculty of Medicine, University of Iceland, 101, Reykjavik, Iceland.
Albert P SigurdssonFaculty of Medicine, University of Iceland, 101, Reykjavik, Iceland.
Katja Van Den HurkDepartment of Donor Studies, Sanquin Research, 1066 CX, Amsterdam, The Netherlands.
Franke QueeDepartment of Donor Studies, Sanquin Research, 1066 CX, Amsterdam, The Netherlands.
Michael W T TanckDepartment of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0001-9828-4459
Willem H OuwehandThe National Institute for Health Research Blood and Transplant Unit in Donor Health and Genomics, University of Cambridge, Cambridge, CB1 8RN, UK.ORCID 0000-0002-7744-1790
David J RobertsThe National Institute for Health Research Blood and Transplant Unit in Donor Health and Genomics, University of Cambridge, Cambridge, CB1 8RN, UK.
Eric J EarleyRTI International, Research Triangle Park, Durham, NC, USA.ORCID 0000-0001-6576-1319
Michael P BuschVitalant Research Institute, San Francisco, CA, USA.ORCID 0000-0002-1446-125X
Alan E MastBlood Research Institute, Versiti, Milwaukee, WI, USA.
Grier P PageRTI International, Atlanta, GA, USA.ORCID 0000-0003-2582-3786
John DaneshThe National Institute for Health Research Blood and Transplant Unit in Donor Health and Genomics, University of Cambridge, Cambridge, CB1 8RN, UK.
Emanuele Di AngelantonioThe National Institute for Health Research Blood and Transplant Unit in Donor Health and Genomics, University of Cambridge, Cambridge, CB1 8RN, UK.
Hreinn StefanssondeCODE Genetics, 101, Reykjavik, Iceland.ORCID 0000-0002-9331-6666
Henrik UllumDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, 2100, Copenhagen, Denmark. henrik.ullum@regionh.dk.
Kari StefanssondeCODE Genetics, 101, Reykjavik, Iceland.ORCID 0000-0003-1676-864X
deCODE Genetics (Iceland) · ISUniversity of Cambridge · GBCopenhagen University Hospital · DKEmory University · USRTI International · USSanquin · NLUniversity of Iceland · ISAarhus University Hospital · DKAmsterdam University Medical Centers · NLDansk Sygehus Institut · DKNational Health Service · GBPacific Research Institute · USUniversity of Copenhagen · DKVersiti Blood Center of Wisconsin · US
Funding
ARACHIDONATE METABOLISM IN GLOMERULONEPHRITIS/VASCULITISK08HL001313 · NHLBI · WASHINGTON UNIVERSITY · PI LEFKOWITH, JAMES B · 1985 to 1988
–British Heart Foundation RG/13/13/30194British Heart Foundation RG/18/13/33946Cancer Research UKDepartment of Health BTRU-2014-10024Medical Research Council MC_UU_00005/8Medical Research Council MC_UU_00006/2Medical Research Council MC_UU_00008/6Medical Research Council MR/L003120/1NCI NIH HHS HHSN261201100006INHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009IWellcome Trust
Abstract
Restless legs syndrome (RLS) is a common neurological sensorimotor disorder often described as an unpleasant sensation associated with an urge to move the legs. Here we report findings from a meta-analysis of genome-wide association studies of RLS including 480,982 Caucasians (cases = 10,257) and a follow up sample of 24,977 (cases = 6,651). We confirm 19 of the 20 previously reported RLS sequence variants at 19 loci and report three novel RLS associations; rs112716420-G (OR = 1.25, P = 1.5 × 10
Indexed as
Genetic Predisposition to DiseaseRestless Legs SyndromeAdultAgedGenome-Wide Association StudyHumansLinkage DisequilibriumMiddle AgedPolymorphism, Single Nucleotide
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.