ArticleScientific reports2020
Metabolomics for early detection of stress in freshwater alga Poterioochromonas malhamensis exposed to silver nanoparticles.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 59 citations in OpenAlex.
- Potential Effects of Gut Microbiota in the Acute and Chronic Toxicity of Silver Nanoparticles toEnvironment & health (Washington, D.C.) · 2026Article
- Metabolomic profiling of diatoms reveals distinct impacts of silver nanoparticles and ions.Environmental science. Nano · 2026Article
- Desiccation-Induced Oxidative Stress Causes Metabolic Flux in the Terrestrial Green Alga Trentepohlia sp., Suggesting Extensive Metabolic Reprogramming for Stress Adaptation.Applied biochemistry and biotechnology · 2026Article
- Microbial response and resistance mechanisms against diverse anthropogenic pollutants.Frontiers in microbiology · 2026Review
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- Multi-Chemical Omics Analysis of the SymbiodiniaceaeMicroorganisms · 2024Article
- The Metabolomics Response ofNanomaterials (Basel, Switzerland) · 2023Article
- The Occurrence of Oxidative Stress Induced by Silver Nanoparticles inNanomaterials (Basel, Switzerland) · 2023Article
- GC-MS based untargeted metabolomics reveals the metabolic response of earthworm (Eudrilus eugeniae) after chronic combinatorial exposure to three different pesticides.Scientific reports · 2023Article
- The toxicity of nanoparticles and their interaction with cells: anNanoscale advances · 2023Review
- Metabolic alterations in algaEnvironmental science. Nano · 2022Article
- The Memory of Rice Response to Spaceflight Stress: From the Perspective of Metabolomics and Proteomics.International journal of molecular sciences · 2022Article
- Aquatic organisms modulate the bioreactivity of engineered nanoparticles: focus on biomolecular corona.Frontiers in toxicology · 2022Review
- Multifarious global flora fabricated phytosynthesis of silver nanoparticles: a green nanoweapon for antiviral approach including SARS-CoV-2.International nano letters · 2022Review
- Metabolomic Response of Early-Stage Wheat (Nanomaterials (Basel, Switzerland) · 2021Article
- Metabolomic Studies for the Evaluation of Toxicity Induced by Environmental Toxicants on Model Organisms.Metabolites · 2021Review
- Microalgal Biodiesel Production: Realizing the Sustainability Index.Frontiers in bioengineering and biotechnology · 2021Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Silver nanoparticles (AgNPs) are one of the most used engineered nanomaterials. Despite progress in assessing their environmental implications, knowledge gaps exist concerning the metabolic perturbations induced by AgNPs on phytoplankton, essential organisms in global biogeochemical cycles and food-web dynamics. We combine targeted metabolomics, biouptake and physiological response studies to elucidate metabolic perturbations in alga Poterioochromonas malhamensis induced by AgNPs and dissolved Ag. We show time-dependent perturbation of the metabolism of amino acids, nucleotides, fatty acids, tricarboxylic acids, photosynthesis and photorespiration by both Ag-treatments. The results suggest that dissolved Ag ions released by AgNPs are the major toxicity driver; however, AgNPs internalized in food vacuoles contributed to the perturbation of amino acid metabolism, TCA cycle and oxidative stress. The metabolic perturbations corroborate the observed physiological responses. We highlight the potential of metabolomics as a tool for understanding the molecular basis for these metabolic and physiological changes, and for early detection of stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.