Evidence map›Paper›PMID 33239717›Full record

ArticleScientific reports2020

A critical role of endothelial cell protein C receptor in the intestinal homeostasis in experimental colitis.

Vijay Kondreddy, Shiva Keshava, Charles T Esmon, Usha R Pendurthi, L Vijaya Mohan Rao

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Tissue factor-dependent colitogenic CD4Nature communications · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Dysregulated haemostasis in thrombo-inflammatory disease.Clinical science (London, England : 1979) · 2022
    Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Vijay KondreddyDepartment of Cellular and Molecular Biology, The University of Texas Health Science Center At Tyler, 11937 US Highway 271, Tyler, TX, 75708-3154, USA.
Shiva KeshavaDepartment of Cellular and Molecular Biology, The University of Texas Health Science Center At Tyler, 11937 US Highway 271, Tyler, TX, 75708-3154, USA.
Charles T EsmonCoagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Usha R PendurthiDepartment of Cellular and Molecular Biology, The University of Texas Health Science Center At Tyler, 11937 US Highway 271, Tyler, TX, 75708-3154, USA.
L Vijaya Mohan RaoDepartment of Cellular and Molecular Biology, The University of Texas Health Science Center At Tyler, 11937 US Highway 271, Tyler, TX, 75708-3154, USA. Vijay.rao@uthct.edu.
The University of Texas Health Science Center at Tyler · USOklahoma Medical Research Foundation · US

Funding

Membrane Phospholipids: The Key Regulators of Tissue Factor Encryption/DecryptionR01HL124055 · NHLBI · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI LELLA, VIJAYA MOHAN RAO · 2015 to 2023
$3.3M
Factor VIIa Interaction with Endothelial Cell Protein C ReceptorR01HL107483 · NHLBI · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI LELLA, VIJAYA MOHAN RAO · 2012 to 2019
$2.9M
NHLBI NIH HHS HL107483NHLBI NIH HHS R01 HL107483NHLBI NIH HHS R01 HL124055
6 · The paper itself

Abstract

Crohn's disease and ulcerative colitis are the two forms of disorders of the human inflammatory bowel disease with unknown etiologies. Endothelial cell protein C receptor (EPCR) is a multifunctional and multiligand receptor, which is expressed on the endothelium and other cell types, including epithelial cells. Here, we report that EPCR is expressed in the colon epithelial cells, CD11c

Indexed as

AnimalsColitisColitis, UlcerativeColonCrohn DiseaseCytokinesDextran SulfateDisease Models, AnimalEndothelial CellsEndothelial Protein C ReceptorFemaleHomeostasisInflammationIntestinal MucosaIntestinesMacrophagesCytokinesDextran SulfateEndothelial Protein C Receptor

Identifiers

PMID33239717
PMCPMC7689504
OpenAlexW3108147303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.