SynthesisNature communications2020
Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 9 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed, 9 pooled it
10.2field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
120 citing papers in PubMed, 9 syntheses or guidelines pooled it, 186 citations in OpenAlex.
- Multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycaemic traits during pregnancy reveals limited evidence of pregnancy-specific genetic effects.Nature communications · 2026Pooled it
- Preeclampsia Genomic Susceptibility Factors in Populations of African Ancestry: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2026Pooled it
- Cross-ancestry genome-wide association study identifies new susceptibility genes for preeclampsia.BMC pregnancy and childbirth · 2025Pooled it
- Association between pregnancy-related complications and development of type 2 diabetes and hypertension in women: an umbrella review.BMC medicine · 2024Pooled it
- Polygenic prediction of preeclampsia and gestational hypertension.Nature medicine · 2023Pooled it
- Genetic effects on the timing of parturition and links to fetal birth weight.Nature genetics · 2023Pooled it
- Pooled it
- The Association Between Hypertensive Disorders in Pregnancy and the Risk of Developing Chronic Hypertension.Frontiers in cardiovascular medicine · 2022Pooled it
- The CD94/NKG2A inhibitory receptor educates uterine NK cells to optimize pregnancy outcomes in humans and mice.Immunity · 2021Pooled it
- Analysis of risk factors and construction of nomograph model for critical condition of patients with hypertension during pregnancy.BMC pregnancy and childbirth · 2023Trial
- The relative importance of neighborhood environment features in explaining preeclampsia risk using machine learning.Pregnancy (Hoboken, N.J.) · 2026Article
- Observational
- Hypertensive Disorders of Pregnancy and Cardiovascular-Kidney-Metabolic Syndrome.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Polymorphic Variant Associated with Sex Hormone-Binding Globulin Level Is a Risk Factor for Preeclampsia.International journal of molecular sciences · 2026Article
- Spatial Logic and Evolutionary Innovation in Human Placentation.bioRxiv : the preprint server for biology · 2026Article
- BMI-Dependent Associations of the Estradiol-Linked Polymorphism rs117585797 of theLife (Basel, Switzerland) · 2026Article
- Therapeutic Interventions for Preeclampsia: Integrating Placental and Maternal Perspectives.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Review
- Mechanisms of Hypertension in Women: Interactions Between Vascular Ageing, Metabolic Dysfunction, and Hormonal Regulation.Biomedicines · 2026Review
- Age at menarche and adverse pregnancy and perinatal outcomes: triangulating evidence from multivariable and Mendelian randomization analyses.International journal of epidemiology · 2026Article
- Cross-species insights into placental evolution and diseases at the single-cell resolution.Nature communications · 2026Article
60 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
77 authors at 20 institutions in 11 countries.
Valgerdur SteinthorsdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland. valgerdur.steinthorsdottir@decode.is.ORCID 0000-0003-1846-6274
Ralph McGinnisWellcome Sanger Institute, Cambridge, UK. rm2@sanger.ac.uk.ORCID 0000-0003-4540-9857
Nicholas O WilliamsWellcome Sanger Institute, Cambridge, UK.ORCID 0000-0003-3989-9167
Lilja StefansdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Gudmar ThorleifssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Scott ShooterWellcome Sanger Institute, Cambridge, UK.
João FadistaDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Jon K SigurdssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Kirsi M AuroFinnish Institute for Health and Welfare, Helsinki, Finland.
Galina BerezinaScientific Center of Obstetrics, Gynecology and Perinatology, Almaty, Kazakhstan.ORCID 0000-0002-5442-4461
Maria-Carolina BorgesMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Suzannah BumpsteadWellcome Sanger Institute, Cambridge, UK.
Jonas Bybjerg-GrauholmDepartment for Congenital Disorders, Danish Centre for Neonatal Screening, Statens Serum Institut, Copenhagen, Denmark.ORCID 0000-0003-1705-4008
Irina ColgiuWellcome Sanger Institute, Cambridge, UK.
Vivien A DolbyLeeds Institute of Medical Research (LIMR), School of Medicine, University of Leeds, Leeds, UK.
Frank DudbridgeDepartment of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0002-8817-8908
Stephanie M EngelDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Christopher S FranklinWellcome Sanger Institute, Cambridge, UK.ORCID 0000-0003-3893-0759
Michael L FriggedeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Yr FrisbaekDepartment of Obstetrics and Gynecology, Landspitali University Hospital, Reykjavik, Iceland.
Reynir T GeirssonDepartment of Obstetrics and Gynecology, Landspitali University Hospital, Reykjavik, Iceland.
Frank GellerDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.ORCID 0000-0002-9238-3269
Solveig GretarsdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Daniel F GudbjartssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID 0000-0002-5222-9857
Quaker HarmonEpidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC, USA.
David Michael HougaardDepartment for Congenital Disorders, Danish Centre for Neonatal Screening, Statens Serum Institut, Copenhagen, Denmark.ORCID 0000-0001-5928-3517
Tatyana HegayInstitute of immunology and human genomics, Uzbek Academy of Sciences, Tashkent, Uzbekistan.
Anna HelgadottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID 0000-0002-1806-2467
Sigrun HjartardottirDepartment of Obstetrics and Gynecology, Landspitali University Hospital, Reykjavik, Iceland.
Tiina JääskeläinenMedical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0002-1202-0936
Hrefna JohannsdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Ingileif JonsdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID 0000-0001-8339-150X
Thorhildur JuliusdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Noor KalshekerSchool of Life Sciences, University of Nottingham, Nottingham, UK.
Abdumadjit KasimovInstitute of immunology and human genomics, Uzbek Academy of Sciences, Tashkent, Uzbekistan.
John P KempMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID 0000-0002-9105-2249
Katja KivinenDivision of Cardiovascular Medicine, University of Cambridge, Cambridge, UK.ORCID 0000-0002-1135-7625
Kari KlungsøyrDivision of Mental and Physical Health, Norwegian Institute of Public Health, Oslo, Norway.
Wai K LeeInstitute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
Mads MelbyeDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.ORCID 0000-0001-8264-6785
Zosia MiedzybrodskaDivision of Applied Medicine, School of Medicine, Medical Sciences, Nutrition and Dentistry, University of Aberdeen, Aberdeen, UK.
Ashley MoffettDepartment of Pathology, University of Cambridge, Cambridge, UK.ORCID 0000-0002-8388-9073
Dilbar NajmutdinovaRepublic Specialized Scientific Practical Medical Centre of Obstetrics and Gynecology, Tashkent, Uzbekistan.
Firuza NishanovaRepublic Specialized Scientific Practical Medical Centre of Obstetrics and Gynecology, Tashkent, Uzbekistan.
Thorunn OlafsdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Markus PerolaFinnish Institute for Health and Welfare, Helsinki, Finland.
Fiona Broughton PipkinSchool of Medicine, University of Nottingham, Nottingham, UK.ORCID 0000-0002-6209-5987
Lucilla PostonDepartment of Women and Children's Health, King's College London, London, UK.
Gordon PrescottDivision of Applied Medicine, School of Medicine, Medical Sciences, Nutrition and Dentistry, University of Aberdeen, Aberdeen, UK.ORCID 0000-0002-9156-2361
Saedis SaevarsdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID 0000-0001-9392-6184
Damilya SalimbayevaScientific Center of Obstetrics, Gynecology and Perinatology, Almaty, Kazakhstan.
Paula Juliet ScaifeSchool of Medicine, University of Nottingham, Nottingham, UK.
Line SkotteDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.ORCID 0000-0002-7398-1271
Eleonora Staines-UriasDepartment of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
Olafur A StefanssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID 0000-0002-9663-3018
Karina Meden SørensenThe Danish National Biobank, Statens Serum Institut, Copenhagen, Danmark.
Liv Cecilie Vestrheim ThomsenDepartment of Clinical Science, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway.
Vinicius TragantedeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Lill TrogstadDepartment of Infectious Disease Epidemiology and Modelling, Norwegian Institute of Public Health, Oslo, Norway.
Nigel A B SimpsonDivision of Womens and Children's Health, School of Medicine, University of Leeds, Leeds, UK.ORCID 0000-0002-0758-7583
FINNPEC Consortium
GOPEC Consortium
Tamara AripovaInstitute of immunology and human genomics, Uzbek Academy of Sciences, Tashkent, Uzbekistan.
Juan P CasasMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Anna F DominiczakInstitute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.ORCID 0000-0003-4913-3608
James J WalkerLeeds Institute of Medical Research (LIMR), School of Medicine, University of Leeds, Leeds, UK.ORCID 0000-0002-8922-083X
Unnur ThorsteinsdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Ann-Charlotte IversenDepartment of Clinical and Molecular Medicine, Centre of Molecular Inflammation Research (CEMIR), Norwegian University of Science and Technology (NTNU), Trondheim, Norway.ORCID 0000-0001-7726-7684
Bjarke FeenstraDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.ORCID 0000-0003-1478-649X
Deborah A LawlorMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID 0000-0002-6793-2262
Heather Allison BoydDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.ORCID 0000-0001-6849-9985
Per MagnusCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Hannele LaivuoriMedical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0003-3212-7826
Nodira ZakhidovaInstitute of immunology and human genomics, Uzbek Academy of Sciences, Tashkent, Uzbekistan.
Gulnara SvyatovaScientific Center of Obstetrics, Gynecology and Perinatology, Almaty, Kazakhstan.ORCID 0000-0001-5092-3143
Kari StefanssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID 0000-0003-1676-864X
Linda MorganSchool of Life Sciences, University of Nottingham, Nottingham, UK.ORCID 0000-0002-2995-4081
deCODE Genetics (Iceland) · ISStatens Serum Institut · DKUniversity of Helsinki · FIUniversity of Nottingham · GBWellcome Sanger Institute · GBAcademy of Sciences Republic of Uzbekistan · UZUniversity of Cambridge · GBUniversity of Glasgow · GBUniversity of Leeds · GBKazakh Institute of Oncology and Radiology · KZNorwegian Institute of Public Health · NOReykjavík University · ISFinnish Institute for Health and Welfare · FIKing's College London · GBLondon School of Hygiene & Tropical Medicine · GBNorwegian University of Science and Technology · NOTashkent Pediatric Medical Institute · UZUniversity of Bristol · GBUniversity of Oxford · GBBrigham and Women's Hospital · US
Funding
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3MPrenatal Smoking, Maternal & Fetal Genetic Variation & Risk of PreeclampsiaR01HD058008 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ENGEL, STEPHANIE · 2008 to 2012
$2.7MBritish Heart Foundation AA/18/7/34219British Heart Foundation RG/99006Department of Health NF-0616-10102Medical Research Council G9815508Medical Research Council MC_EX_MR/M009203/1Medical Research Council MC_PC_14089Medical Research Council MC_PC_15018Medical Research Council MC_PC_17228Medical Research Council MC_PC_19009Medical Research Council MC_QA137853Medical Research Council MC_UU_00011/6Medical Research Council MR/M009203/1Medical Research Council MR/P014054/1NICHD NIH HHS R01 HD058008NIEHS NIH HHS P30 ES010126Wellcome Trust 098051Wellcome Trust 102215/2/13/2Wellcome Trust WT088806
Abstract
Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.
Indexed as
Genetic Predisposition to DiseaseMultifactorial InheritanceAdaptor Proteins, Signal TransducingAdultAgedAlpha-Ketoglutarate-Dependent Dioxygenase FTOAsia, CentralBlood PressureCase-Control StudiesDatasets as TopicEuropeFemaleFibroblast Growth Factor 5Genetic LociGenome-Wide Association StudyHumansAdaptor Proteins, Signal TransducingAlpha-Ketoglutarate-Dependent Dioxygenase FTOFGF5 protein, humanFibroblast Growth Factor 5FTO protein, humanMDS1 and EVI1 Complex Locus ProteinMECOM protein, humanSH2B3 protein, human
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