Evidence map›Paper›PMID 33239690›Full record

ArticleScientific reports2020

Single cell profiling of capillary blood enables out of clinic human immunity studies.

Tatyana Dobreva, David Brown, Jong Hwee Park, Matt Thomson

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Tatyana DobrevaAndrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, Pasadena, CA, USA. tdobreva@caltech.edu.
David BrownDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Jong Hwee ParkDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Matt ThomsonDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. mthomson@caltech.edu.
California Institute of Technology · US

Funding

Predoctoral Training in Quantitative NeuroscienceT32NS105595 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI MARKUS MEISTER · 2019 to 2026
$2.6M
NINDS NIH HHS T32 NS105595
6 · The paper itself

Abstract

An individual's immune system is driven by both genetic and environmental factors that vary over time. To better understand the temporal and inter-individual variability of gene expression within distinct immune cell types, we developed a platform that leverages multiplexed single-cell sequencing and out-of-clinic capillary blood extraction to enable simplified, cost-effective profiling of the human immune system across people and time at single-cell resolution. Using the platform, we detect widespread differences in cell type-specific gene expression between subjects that are stable over multiple days.

Indexed as

Gene Expression ProfilingSingle-Cell AnalysisBloodCapillariesCircadian RhythmFemaleGene Expression RegulationHumansImmunityMale

Identifiers

PMID33239690
PMCPMC7688970
OpenAlexW3110592098

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.