SynthesisNature communications2020
The genetic architecture of sporadic and multiple consecutive miscarriage.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 7 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 7 pooled it
16.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 7 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- Thyroid disorders and pregnancy loss: a bidirectional mendelian randomization exploration.BMC pregnancy and childbirth · 2025Pooled it
- Immunological Indicators of Recurrent Pregnancy Loss: A Mendelian Randomization Study.Reproductive sciences (Thousand Oaks, Calif.) · 2024Pooled it
- Meta-regression of genome-wide association studies to estimate age-varying genetic effects.European journal of epidemiology · 2024Pooled it
- Multi-ancestry meta-analysis and fine-mapping in Alzheimer's disease.Molecular psychiatry · 2023Pooled it
- Genetic effects on the timing of parturition and links to fetal birth weight.Nature genetics · 2023Pooled it
- Mendelian randomization study of maternal coffee consumption and its influence on birthweight, stillbirth, miscarriage, gestational age and pre-term birth.International journal of epidemiology · 2023Pooled it
- Pooled it
- Gut microbiota‑immune crosstalk in recurrent pregnancy loss: Mechanisms and therapeutic perspectives (Review).Molecular medicine reports · 2026Review
- Cross-species insights into placental evolution and diseases at the single-cell resolution.Nature communications · 2026Article
- Article
- Prescribed hormonal contraceptive use trends in the Estonian Biobank: A longitudinal observational study.PLoS medicine · 2026Observational
- Leveraging health records to identify diagnoses associated with recurrent pregnancy loss across two medical centers.iScience · 2026Article
- Identifying the Genetic Basis of Fetal Loss in Cows and Heifers Through a Genome-Wide Association Analysis.Animals : an open access journal from MDPI · 2026Article
- Genetically Causal Associations Between Adenomyosis/Endometriosis and Adverse Pregnancy Outcomes - A Two-Sample Mendelian Randomization Study.International journal of women's health · 2026Article
- Integrative Multi-Omics Analysis Unveils Biomarkers Linking the Gut Microbiota, Blood Metabolites, and Recurrent Pregnancy Loss.International journal of women's health · 2026Article
- Genomics of pregnancy loss.Journal of assisted reproduction and genetics · 2026Review
- Placental biology links genetic, epigenetic, ancestral, and social determinants to maternal-fetal health inequities.Frontiers in reproductive health · 2026Review
- Polycystic ovary syndrome and miscarriage risk: dual evidence from cohort study and Mendelian randomization.Frontiers in endocrinology · 2026Article
- Association of serum anti-Müllerian hormone levels with early miscarriage: a retrospective cohort and mendelian randomization study.Reproductive biology and endocrinology : RB&E · 2025Article
- Bisphenol F-TLR4 interaction: uncovering new mechanisms in unexplained miscarriage.EBioMedicine · 2025Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
55 authors at 20 institutions in 10 countries.
Triin LaiskDepartment of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia. triin.laisk@ut.ee.ORCID 0000-0003-1501-9030
Ana Luiza G SoaresMRC Integrated Epidemiology Unit at the University of Bristol, Bristol, UK.ORCID 0000-0003-2763-4647
Teresa FerreiraBig Data Institute, Li Ka Shing Center for Health for Health Information and Discovery, Oxford University, Oxford, UK.
Jodie N PainterQIMR Berghofer Medical Research Institute, Herston, QLD, Australia.ORCID 0000-0002-4992-2458
Jenny C CensinBig Data Institute, Li Ka Shing Center for Health for Health Information and Discovery, Oxford University, Oxford, UK.ORCID 0000-0001-6625-6074
Samantha LaberBig Data Institute, Li Ka Shing Center for Health for Health Information and Discovery, Oxford University, Oxford, UK.
Jonas BacelisDepartment of Obstetrics and Gynecology, Sahlgrenska University Hospital Östra, Gothenburg, Sweden.ORCID 0000-0002-2450-732X
Chia-Yen ChenAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Maarja LepametsEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Kuang LinClinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Siyang LiuBGI-Shenzhen, Shenzhen, 518083, Guangdong, China.
Iona Y MillwoodClinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Avinash RamuDepartment of Genetics, Washington University in St. Louis, Saint Louis, MO, USA.
Jennifer SouthcombeNuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK.
Marianne S AndersenDepartment of Endocrinology, Odense University Hospital, Odense, Denmark.
Ling YangClinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Christian M BeckerNuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK.ORCID 0000-0002-9870-9581
Anders D BørglumiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.ORCID 0000-0001-8627-7219
Scott D GordonQIMR Berghofer Medical Research Institute, Herston, QLD, Australia.ORCID 0000-0001-7623-328X
Jonas Bybjerg-GrauholmiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.ORCID 0000-0003-1705-4008
Øyvind HelgelandDepartment of Genetics and Bioinformatics, Health Data and Digitalisation, Norwegian Institute of Public Health, Oslo, Norway.
David M HougaardiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.ORCID 0000-0001-5928-3517
Xin JinBGI-Shenzhen, Shenzhen, 518083, Guangdong, China.
Stefan JohanssonKG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, N-5020, Bergen, Norway.ORCID 0000-0002-2298-7008
Julius JuodakisDepartment of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0001-5600-974X
Christiana KartsonakiClinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Viktorija KukushkinaEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Penelope A LindQIMR Berghofer Medical Research Institute, Herston, QLD, Australia.ORCID 0000-0002-3887-2598
Andres MetspaluEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID 0000-0002-3718-796X
Grant W MontgomeryUniversity of Queensland, St Lucia, QLD, Australia.ORCID 0000-0002-4140-8139
Andrew P MorrisEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID 0000-0002-6805-6014
Ole MorsiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Preben B MortenseniPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Pål R NjølstadKG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, N-5020, Bergen, Norway.ORCID 0000-0003-0304-6728
Merete NordentoftiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Dale R NyholtSchool of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia.ORCID 0000-0001-7159-3040
Margaret LippincottReproductive Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA.
Stephanie SeminaraReproductive Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA.
Andres SalumetsDepartment of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID 0000-0003-1949-2298
Krina ZondervanWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID 0000-0002-0275-9905
Thomas WergeiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.ORCID 0000-0003-1829-0766
Zhengming ChenClinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID 0000-0001-6423-105X
Donald F ConradDepartment of Genetics, Washington University in St. Louis, Saint Louis, MO, USA.
Bo JacobssonDepartment of Obstetrics and Gynecology, Sahlgrenska University Hospital Östra, Gothenburg, Sweden.ORCID 0000-0001-5079-2374
Liming LiDepartment of Epidemiology & Biostatistics, Peking University Health Science Centre, Peking University, Beijing, China.ORCID 0000-0001-5873-7089
Nicholas G MartinQIMR Berghofer Medical Research Institute, Herston, QLD, Australia.ORCID 0000-0003-4069-8020
Benjamin M NealeAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-1513-6077
Rasmus NielsenDepartment of Integrative Biology, University of California Berkeley, Berkeley, CA, USA.ORCID 0000-0003-0513-6591
Robin G WaltersClinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID 0000-0002-9179-0321
Ingrid GranneNuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK.
Sarah E MedlandQIMR Berghofer Medical Research Institute, Herston, QLD, Australia.ORCID 0000-0003-1382-380X
Reedik MägiEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Deborah A LawlorMRC Integrated Epidemiology Unit at the University of Bristol, Bristol, UK.ORCID 0000-0002-6793-2262
Cecilia M LindgrenBig Data Institute, Li Ka Shing Center for Health for Health Information and Discovery, Oxford University, Oxford, UK. cecilia.lindgren@bdi.ox.ac.uk.ORCID 0000-0002-4903-9374
University of Oxford · GBQIMR Berghofer Medical Research Institute · AUCentre for Human Genetics · GBUniversity of Tartu · EEBroad Institute · USAarhus University · DKBGI Group (China) · CNHaukeland University Hospital · NOMassachusetts General Hospital · USNorwegian Institute of Public Health · NOStatens Serum Institut · DKUniversity of Bristol · GBUniversity of Copenhagen · DKWashington University in St. Louis · USAarhus University Hospital · DKCompetence Centre on Health Technologies (Estonia) · EEHealth Data Research UK · GBMental Health Services · DKOdense University Hospital · DKPeking University · CN
Funding
Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9MA Center for GEI Association StudiesU01HG004424 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2007 to 2010
$21.4MFinding Genomic Profiles of COVID-19 Phenotypes from the EHRU01HG008685 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIZABETH W KARLSON, Matthew S Lebo · 2015 to 2026
$13.6MThe Genetic Determinants of Human GNRH DeficiencyP50HD028138 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI SEMINARA, STEPHANIE BETH · 2014 to 2020
$12.9MNorway Mother & Child Cohort Study (MoBa) Continued Specimen Collection, and Tools to Enhance Use and CollaborationN01ES75558 · NIEHS · NORWEGIAN INSTITUTE OF PUBLIC HEALTH · PI MAGNUS, PER · 2007 to 2016
$11.8MSNP HEALTH ASSOCIATION RESOURCE (SHARE)N02HL64278 · NHLBI · PI CHIN, SIANG · 2007 to 2007
$9.2MGENOMICS OF SPERMATOGENIC IMPAIRMENTR01HD078641 · NICHD · WASHINGTON UNIVERSITY · PI Kenneth Ivan Aston, DONALD F. CONRAD · 2014 to 2026
$6.3MGWAS of Hormone Treatment and CVD and Metabolic Outcomes in the WHIU01HG005152 · NHGRI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI REINER, ALEXANDER P · 2009 to 2011
$2.6MRandomized Clinical Trials - Whole Genome Studies Coordinating CenterU01HG005157 · NHGRI · UNIVERSITY OF WASHINGTON · PI HEAGERTY, PATRICK J, WEIR, BRUCE S. · 2009 to 2011
$2.4MMetabolomic and Epigenomic Mechanisms in Developmental Overnutrition.R01DK103246 · NIDDK · UNIVERSITY OF BRISTOL · PI LAWLOR, DEBORAH ANNE · 2014 to 2018
$2.2MMODELING THE EFFECTS OF STRUCTURAL VARIATION IN GTEX DATA AND MENDELIAN DISEASER01MH101810 · NIMH · WASHINGTON UNIVERSITY · PI CONRAD, DONALD F. · 2013 to 2016
$1.3MSLEEP AND ENTRAINMENT OF SCN FUNCTIONR01HL064278 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI STROHL, KINGMAN PERKINS · 1999 to 2002
$871kBritish Heart FoundationDepartment of HealthMedical Research Council G9815508Medical Research Council MC-PC-13049Medical Research Council MC_PC_13049Medical Research Council MC-PC-14135Medical Research Council MC_PC_14135Medical Research Council MC_PC_15018Medical Research Council MC_PC_17228Medical Research Council MC_PC_19009Medical Research Council MC_QA137853Medical Research Council MC_U137686851Medical Research Council MC_UU_00011/6Medical Research Council MC_UU_00017/1Medical Research Council MC_UU_12026/2NHGRI NIH HHS U01 HG004424NHGRI NIH HHS U01 HG005152NHGRI NIH HHS U01 HG005157NHGRI NIH HHS U01 HG008685NHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS N02 HL64278NICHD NIH HHS K23 HD097296NICHD NIH HHS P50 HD028138NICHD NIH HHS R01 HD078641NIDDK NIH HHS R01 DK103246NIEHS NIH HHS N01ES75558NIH HHS P51 OD011092NIMH NIH HHS R01 MH101810Wellcome TrustWellcome Trust 088158/Z/09/ZWellcome Trust 102215/2/13/2Wellcome Trust 104085/Z/14/ZWellcome Trust 202922/Z/16/ZWellcome Trust 203141/Z/16/ZWellcome Trust WT088806
Abstract
Miscarriage is a common, complex trait affecting ~15% of clinically confirmed pregnancies. Here we present the results of large-scale genetic association analyses with 69,054 cases from five different ancestries for sporadic miscarriage, 750 cases of European ancestry for multiple (≥3) consecutive miscarriage, and up to 359,469 female controls. We identify one genome-wide significant association (rs146350366, minor allele frequency (MAF) 1.2%, P = 3.2 × 10
Indexed as
Genetic Predisposition to DiseaseAbortion, HabitualAbortion, SpontaneousAdultAgedCase-Control StudiesDatasets as TopicFemaleGene FrequencyGenome-Wide Association StudyHumansInheritance PatternsMedical History TakingMiddle AgedPlacentaPolymorphism, Single Nucleotide
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.