ArticleProceedings of the National Academy of Sciences of the United States of America2020
Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers.
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159citing papers in PubMed
15.8field-weighted citation impact, top 1% of its field
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Who cites it
159 citing papers in PubMed, 245 citations in OpenAlex.
- A CRISPR activation screen identifies CH25H as a restriction factor against influenza viruses by targeting accessible cholesterol.Emerging microbes & infections · 2026Article
- Circulating cholesterol fuels SARS-CoV-2 replication via ORF3a.EMBO reports · 2026Article
- The cholesterol transporter Niemann-Pick C1 facilitates the entry of porcine epidemic diarrhea coronavirus.Journal of virology · 2026Article
- Behind the membranous curtain-lipid dynamics and functions in coronaviral replication.Journal of virology · 2026Review
- Therapeutic Innovations for Monkeypox Inhibition.International journal of molecular sciences · 2026Review
- The cGAS-STING pathway at the crossroads of neuroimmunology: bridging innate immunity to aging and neurodegeneration.Biomarker research · 2026Review
- STAT1 signaling controls cholesterol metabolism in epithelial cells and RSV-induced syncytia formation.Npj viruses · 2026Article
- Host Responses to SARS-CoV-2 with an Emphasis on Cytokines.International journal of molecular sciences · 2026Review
- The implications of FASN in viral infection and related diseases: a promising target in antiviral therapies.Frontiers in cellular and infection microbiology · 2026Review
- Serum lipidome remodeling in viral pneumonia: from pathophysiology to therapeutics.Frontiers in immunology · 2026Review
- 25-Hydroxycholesterol restricts human norovirus replication in human intestinal enteroids.Journal of virology · 2025Article
- Nasal mucus-derived KLK13 restricts SARS-CoV-2 infection via proteolytic cleavage of spike.mBio · 2025Article
- Article
- Mechanisms of Cell-Cell Fusion in SARS-CoV-2: An Evolving Strategy for Transmission and Immune Evasion.Viruses · 2025Review
- Membrane-wide screening identifies potential tissue-specific determinants of SARS-CoV-2 tropism.PLoS pathogens · 2025Article
- Cholesterol 25-hydroxylase inhibits Newcastle disease virus replication by enzyme activity-dependent and direct interaction with nucleocapsid protein.Journal of virology · 2025Article
- PINLYP-mediated phospholipid metabolism reprogramming contributes to chronic herpesvirus infection.PLoS pathogens · 2025Article
- PLSCR1 suppresses SARS-CoV-2 infection by downregulating cell surface ACE2.Journal of virology · 2025Article
- SARS-CoV-2 entry and fusion are independent of ACE2 localization to lipid rafts.Journal of virology · 2025Article
- Probing SARS-CoV-2 membrane binding peptide via single-molecule AFM-based force spectroscopy.Nature communications · 2025Article
99 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
27 authors at 7 institutions in 3 countries.
Ruochen ZangDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110.ORCID 0000-0002-8496-7862
James Brett CaseDepartment of Medicine, Division of Infectious Diseases, Washington University School of Medicine in St. Louis, St. Louis, MO 63110.
Eylan YutucSwansea University Medical School, SA2 8PP Swansea, United Kingdom.ORCID 0000-0001-9971-1950
Xiucui MaCenter for Cardiovascular Research and Division of Cardiology, Department of Internal Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO 63111.
Sheng ShenDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202.
Maria Florencia Gomez CastroDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110.ORCID 0000-0003-4081-7819
Zhuoming LiuDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110.ORCID 0000-0001-8198-0976
Qiru ZengDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110.
Haiyan ZhaoDepartment of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110.
Juhee SonDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110.
Paul W RothlaufDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110.ORCID 0000-0002-0941-4467
Alex J B KreutzbergerProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.
Gaopeng HouDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110.
Hu ZhangDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202.ORCID 0000-0002-7447-8360
Sayantan BoseAutonomous Therapeutics, Inc., New York, NY 10013.ORCID 0000-0003-2397-4740
Xin WangKey Laboratory of Marine Drugs, Ministry of Education, Ocean University of China, 266100 Qingdao, China.ORCID 0000-0001-7467-6060
Michael D VaheyDepartment of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO 63110.
Kartik ManiCenter for Cardiovascular Research and Division of Cardiology, Department of Internal Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO 63111.ORCID 0000-0002-4951-3478
William J GriffithsSwansea University Medical School, SA2 8PP Swansea, United Kingdom.ORCID 0000-0002-4129-6616
Tom KirchhausenProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.ORCID 0000-0003-0559-893X
Daved H FremontDepartment of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110.ORCID 0000-0002-8544-2689
Haitao GuoDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202.ORCID 0000-0002-7146-916X
Abhinav DiwanCenter for Cardiovascular Research and Division of Cardiology, Department of Internal Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO 63111.ORCID 0000-0001-7554-4772
Yuqin WangSwansea University Medical School, SA2 8PP Swansea, United Kingdom.ORCID 0000-0002-3063-3066
Michael S DiamondDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110.
Sean P J WhelanDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110.ORCID 0000-0003-1564-8590
Siyuan DingDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110; siyuan.ding@wustl.edu.ORCID 0000-0002-5338-260X
Washington University in St. Louis · USIndiana University School of MedicineSwansea University · GBBoston Children's Hospital · USAutonomous Healthcare · USHarvard University · USOcean University of China · CN
Funding
Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8MCOVID Supplement B Cell Epitope Discovery and Mechanisms of Antibody Protection.75N93019C00062 · NIAID · WASHINGTON UNIVERSITY · PI FREMONT, DAVED · 2019 to 2023
$11.7MMOLECULAR BASIS OF VIRAL INFECTIVITYT32AI007245 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Aaron Gregory Schmidt · 1985 to 2026
$11.3MROLE OF AUTOPHAGIC FLUX IN CARDIAC MYOCYTE VIABILITYR01HL107594 · NHLBI · WASHINGTON UNIVERSITY · PI Abhinav Diwan · 2011 to 2026
$5.9MRNA Processing in Non-Segmented Minus-Strand RNA VirusesR37AI059371 · NIAID · WASHINGTON UNIVERSITY · PI WHELAN, SEAN PJ · 2015 to 2024
$5.4MVISUALIZATION OF SUBCELLULAR DYNAMICS IN MULTICELLULAR ORGANISMSR35GM130386 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI TOMAS KIRCHHAUSEN · 2019 to 2026
$4.0MHuman neutralizing antibodies for Zika virusR01AI127828 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CROWE, JAMES E, DIAMOND, MICHAEL S · 2017 to 2021
$3.9MInterferon-Stimulated Gene Inhibition of Rotavirus Replication and Viral AntagonismR01AI150796 · NIAID · WASHINGTON UNIVERSITY · PI DING, SIYUAN · 2020 to 2024
$2.0MGenetic and Biochemical Interrogation of Rotavirus-Cohesin InteractionR00AI135031 · NIAID · WASHINGTON UNIVERSITY · PI DING, SIYUAN · 2020 to 2021
$498kTargeting Macrophage Lysosome Biogenesis Program in Cardiomyopathy and Heart FailureI01BX004235 · VA · ST. LOUIS VA MEDICAL CENTER · PI DIWAN, ABHINAV · 2018 to 2021
–BLRD VA I01 BX004235NHLBI NIH HHS R01 HL107594NIAID NIH HHS 75N93019C00062NIAID NIH HHS R00 AI135031NIAID NIH HHS R01 AI127828NIAID NIH HHS R01 AI150796NIAID NIH HHS R37 AI059371NIAID NIH HHS T32 AI007245NIDDK NIH HHS P30 DK052574NIGMS NIH HHS R35 GM130386NIH HHS GM130386
Abstract
Cholesterol 25-hydroxylase (
Indexed as
COVID-19 Drug TreatmentAntiviral AgentsCOVID-19EndosomesHumansHydroxycholesterolsInterferonsMembrane FusionSARS-CoV-2Severe acute respiratory syndrome-related coronavirusSpike Glycoprotein, CoronavirusVirus InternalizationVirus Replication25-hydroxycholesterolAntiviral AgentsHydroxycholesterolsInterferonsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2COVID-19innate immunityinterferonSARS-CoV-2virus entry
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.