ArticleJournal of neurology, neurosurgery, and psychiatry2020
Plaque morphology in acute symptomatic intracranial atherosclerotic disease.
Article in Journal of neurology, neurosurgery, and psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06404242 (Plaque Characteristics From Vessel Wall Magnetic Resonance Imaging Predict Recurrent Stroke in Ischemic Stroke Patients Due to Middle Cerebral Artery Stenosis), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Plaque Characteristics From Vessel Wall Magnetic Resonance Imaging Predict Recurrent Stroke in Ischemic Stroke Patients Due to Middle Cerebral Artery Stenosis
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- High-risk plaque characteristics associated with recurrent stroke in patients with intracranial stenosis: a systematic review and meta-analysis.Journal of neurology · 2025Pooled it
- Geometry of Terminal Internal Carotid Artery Bifurcation May Be Associated With Middle Cerebral Artery Plaque Ulceration: A Three-Dimensional Rotational Angiography Study.Journal of stroke · 2024Article
- The hemodynamic and geometric characteristics of carotid artery atherosclerotic plaque formation.Quantitative imaging in medicine and surgery · 2024Article
- Identification of symptomatic carotid artery plaque: a predictive model combining angiography with optical coherence tomography.Frontiers in neurology · 2024Article
- Preliminary results on temporal evolution and clinical implications of atherosclerotic plaque in branch atheromatous disease after statin treatment.Therapeutic advances in neurological disorders · 2024Article
- Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics.Stroke and vascular neurology · 2023Article
- Genome sequencing reveals the role of rare genomic variants in Chinese patients with symptomatic intracranial atherosclerotic disease.Stroke and vascular neurology · 2022Article
- Intracranial Arterial Calcification and Intracranial Atherosclerosis: Close but Different.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
26 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntracranial atherosclerotic disease (ICAD) is globally a major ischaemic stroke subtype with high recurrence. Understanding the morphology of symptomatic ICAD plaques, largely unknown by far, may help identify vulnerable lesions prone to relapse.
methodsWe prospectively recruited patients with acute ischaemic stroke or transient ischaemic attack attributed to high-grade ICAD (60%-99% stenosis). Plaque morphological parameters were assessed in three-dimensional rotational angiography, including surface contour, luminal stenosis, plaque length/thickness, upstream shoulder angulation, axial/longitudinal plaque distribution and presence of adjoining branch atheromatous disease (BAD). We compared morphological features of smooth, irregular and ulcerative plaques and correlated them with cerebral ischaemic lesion load downstream in MRI.
resultsAmong 180 recruited patients (median age=60 years; 63.3% male; median stenosis=75%), plaque contour was smooth (51 (28.3%)), irregular (101 (56.1%)) or ulcerative (28 (15.6%)). Surface ulcers were mostly at proximal (46.4%) and middle one-third (35.7%) of the lesions. Most (84.4%) plaques were eccentric, and half had their maximum thickness over the distal end. Ulcerative lesions were thicker (medians 1.6 vs 1.3 mm; p=0.003), had steeper upstream shoulder angulation (56.2° vs 31.0
conclusionsUlcerative intracranial atherosclerotic plaques were associated with vulnerable morphological features and had a higher cumulative infarct load downstream.
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