ArticleBMJ open respiratory research2020
Relative contributions of family history and a polygenic risk score on COPD and related outcomes: COPDGene and ECLIPSE studies.
Article in BMJ open respiratory research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Evaluating risk for alcohol use disorder: Polygenic risk scores and family history.Alcoholism, clinical and experimental research · 2022Pooled it
- Evaluating the impact of family history and polygenic risk scores on cardiometabolic disease risk.BMC medicine · 2026Article
- Clinical characteristics and outcomes of chronic obstructive pulmonary disease patients with family history of chronic airway disease.Annals of medicine · 2025Article
- Towards early detection and disease interception of COPD across the lifespan.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Proteomic networks and related genetic variants associated with smoking and chronic obstructive pulmonary disease.BMC genomics · 2024Article
- Exploring the genetics of airflow limitation in lung function across the lifespan - a polygenic risk score study.EClinicalMedicine · 2024Article
- Prevalence, mortality and risk factors for self-reported COPD among smokers and never smokers, NHANES 1999-2018.Tobacco induced diseases · 2024Article
- Polygenic risk scores identify heterogeneity in asthma and chronic obstructive pulmonary disease.The Journal of allergy and clinical immunology · 2023Article
- Systematic comparison of family history and polygenic risk across 24 common diseases.American journal of human genetics · 2022Article
- Polygenic scores for low lung function and the future risk of adverse health outcomes.Cardiovascular diabetology · 2022Article
- A polygenic risk score and age of diagnosis of COPD.The European respiratory journal · 2022Article
- Incorporating family history of disease improves polygenic risk scores in diverse populations.Cell genomics · 2022Article
- Recent advancements in understanding the genetic involvement of alpha-1 antitrypsin deficiency associated lung disease: a look at future precision medicine approaches.Expert review of respiratory medicine · 2022Review
- Parental COPD as a Risk Factor for the Development of COPD and Disease Severity in Offspring: A Systematic Scoping Review.International journal of chronic obstructive pulmonary disease · 2022Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
Abstract
introductionFamily history is a risk factor for chronic obstructive pulmonary disease (COPD). We previously developed a COPD risk score from genome-wide genetic markers (Polygenic Risk Score, PRS). Whether the PRS and family history provide complementary or redundant information for predicting COPD and related outcomes is unknown.
methodsWe assessed the predictive capacity of family history and PRS on COPD and COPD-related outcomes in non-Hispanic white (NHW) and African American (AA) subjects from COPDGene and ECLIPSE studies. We also performed interaction and mediation analyses.
resultsIn COPDGene, family history and PRS were significantly associated with COPD in a single model (P
conclusionFamily history and the PRS provide complementary information for predicting COPD and related outcomes. Future studies can address the impact of obtaining both measures in clinical practice.
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