ArticleGenome research2021
Deep metagenomics examines the oral microbiome during dental caries, revealing novel taxa and co-occurrences with host molecules.
Article in Genome research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
90 citing papers in PubMed, 134 citations in OpenAlex.
- Effect of a sodium fluoride rinse on the composition of early oral biofilms formed in situ on enamel and dentine.Clinical oral investigations · 2026Trial
- Effect of a multichannel oral irrigator on periodontal health and the oral microbiome.Scientific reports · 2023Trial
- Association Between the Root Canal Microbiome and Apical Lesion Size: An Observational Shotgun Metagenomic Study.International endodontic journal · 2026Observational
- Salivary microbiome and metabolome profiles associated with dental caries in Tibetan children from high-altitude regions.Odontology · 2026Article
- Article
- Microbial Composition of Carious Dentin and the Impact of Minimally Invasive Excavation Techniques: A Narrative Review.International journal of molecular sciences · 2026Review
- Three novel Rothia species associated with Antarctic birds harbour novel biosynthetic gene clusters.FEMS microbiology ecology · 2026Article
- Oral-Rinse-Sourced Microbiota in Oral Health and Diseases in a Representative US Adult Population: Implications for Diagnostics.Journal of clinical periodontology · 2026Article
- Prevotella denticola promotes caries by inducing oral microbial dysbiosis.BMC oral health · 2026Article
- Food-grade Lacticaseibacillus paracasei postbiotics suppress oral Streptococcus mutans biofilm formation and cariogenicity.NPJ science of food · 2026Article
- Invasive CSP-1-Capnocytophaga gingivalis in a 60 year-old female with severe neutropenia.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Pulpitis as a microbial disease: single-cell insights into host responses and diagnostic biomarkers for vital pulp therapy.Journal of oral microbiology · 2026Review
- Mapping the oral microbiome in children with oral diseases using next-generation sequencing: a systematic review.Journal of oral microbiology · 2026Review
- Occlusal types shape oral microbiome stomatotypes and metabolic landscapes: A multi-omics perspective on host-microbe interaction.Microbial cell (Graz, Austria) · 2026Article
- Omics insights into the impact of slightly acidic electrolyzed water with sodium benzoate on food and oral associated microbes.Current research in food science · 2026Article
- Oral microbiota: Roles and treatment in radiation injury (Review).Oncology letters · 2025Review
- The salivary virome during childhood dental caries.mSphere · 2025Article
- Seven genome sequences ofMicrobiology resource announcements · 2025Article
- Effects of Antiseptic Formulations on Oral Microbiota and Related Systemic Diseases: A Scoping Review.Antibiotics (Basel, Switzerland) · 2025Review
- Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Dental caries, the most common chronic infectious disease worldwide, has a complex etiology involving the interplay of microbial and host factors that are not completely understood. In this study, the oral microbiome and 38 host cytokines and chemokines were analyzed across 23 children with caries and 24 children with healthy dentition. De novo assembly of metagenomic sequencing obtained 527 metagenome-assembled genomes (MAGs), representing 150 bacterial species. Forty-two of these species had no genomes in public repositories, thereby representing novel taxa. These new genomes greatly expanded the known pangenomes of many oral clades, including the enigmatic Saccharibacteria clades G3 and G6, which had distinct functional repertoires compared to other oral Saccharibacteria. Saccharibacteria are understood to be obligate epibionts, which are dependent on host bacteria. These data suggest that the various Saccharibacteria clades may rely on their hosts for highly distinct metabolic requirements, which would have significant evolutionary and ecological implications. Across the study group,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.