ArticleScience translational medicine2020
Obesity induces gut microbiota alterations and augments acute graft-versus-host disease after allogeneic stem cell transplantation.
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Article in Science translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
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Who cites it
39 citing papers in PubMed, 47 citations in OpenAlex.
- Higher abatacept exposure after transplant decreases acute GVHD risk without increasing adverse events.Blood · 2023Trial
- The Role of the Gut Microbiota in Allogeneic Hematopoietic Cell Transplantation.American journal of hematology · 2026Review
- Review
- Dietary animal fat disrupts gut microbiota and aggravates Scl-cGVHD after allogeneic hematopoietic stem cell transfer.Blood advances · 2026Article
- Secondary failure of platelet recovery after allogeneic hematopoietic stem cell transplantation in pediatric acquired aplastic anemia: Incidence, risk factors, and clinical outcomes.Clinical hematology international · 2026Article
- Methionine Supplementation Benefits Lipogenesis in Goat Intramuscular Adipocytes, Likely by Inhibiting the Expression ofAnimals : an open access journal from MDPI · 2025Article
- Chronic Graft-versus-host Disease, Part 1: How Preclinical Models Shape Our Understanding of Biology and Pave the Way for Future Therapeutic Interventions.Transplantation · 2025Review
- Gut microbiota and acute graft-versus-host disease.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025Article
- Breaking down barriers: is intestinal mucus degradation byInfection and immunity · 2025Review
- Pediatric Transplant and Cellular Therapy Consortium RESILIENT Conference on Pediatric Chronic Graft-versus-Host Disease Survivorship after Hematopoietic Cell Transplantation: Part III. Long-Term Impact of Chronic Graft-versus-Host Disease on Endocrinologic, Cardiovascular, and Metabolic Outcomes in Survivors of Pediatric Hematopoietic Cell Transplantation.Transplantation and cellular therapy · 2025Article
- Hematopoietic stem cells: Understanding the mechanisms to unleash the therapeutic potential of hematopoietic stem cell transplantation.Stem cell research & therapy · 2025Review
- Advancing therapeutic strategies for graft-versus-host disease by targeting gut microbiome dynamics in allogeneic hematopoietic stem cell transplantation: current evidence and future directions.Molecular medicine (Cambridge, Mass.) · 2025Review
- Impact of pre-transplant body mass index on outcomes in AML patients aged ≥ 50 years after allogeneic hematopoietic cell transplantation.Frontiers in immunology · 2025Article
- Free fatty acid receptor-4 regulates T-cell-mediated allogeneic reaction through activating an aryl hydrocarbon receptor pathway.Acta pharmaceutica Sinica. B · 2025Article
- Article
- Whole genome sequencing of mouse lines divergently selected for fatness (FLI) and leanness (FHI) revealed several genetic variants as candidates for novel obesity genes.Genes & genomics · 2024Article
- Role of the microbiota in response to and recovery from cancer therapy.Nature reviews. Immunology · 2024Review
- The impact of pre-transplantation diabetes and obesity on acute graft-versus-host disease, relapse and death after allogeneic hematopoietic cell transplantation: a study from the EBMT Transplant Complications Working Party.Bone marrow transplantation · 2024Article
- Potential roles of sex-linked differences in obesity and cancer immunotherapy: revisiting the obesity paradox.npj metabolic health and disease · 2024Review
- Genetic and pharmaceutical targeting of HIF1α allows combo-immunotherapy to boost graft vs. leukemia without exacerbation graft vs. host disease.Cell reports. Medicine · 2023Article
Corrections and comments
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Authors and funding
27 authors at 8 institutions in 1 country.
Lam T KhuatDepartment of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.ORCID 0000-0002-4223-8805
Catherine T LeDepartment of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.ORCID 0000-0002-0175-570X
Chien-Chun Steven PaiDepartment of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.
Robin R Shields-CutlerDepartment of Biology, Macalester College, Saint Paul, MN 55105, USA.ORCID 0000-0003-4701-9895
Shernan G HoltanBlood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA.
Armin RashidiBlood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA.
Sarah L ParkerDepartment of Internal Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
Dan KnightsDepartment of Computer Science and Engineering, Biotechnology Institute, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-8205-2511
Jesus I LunaDepartment of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.ORCID 0000-0002-6809-3333
Cordelia DunaiDepartment of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.ORCID 0000-0001-5799-2387
Ziming WangDepartment of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.
Ian R SturgillDepartment of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.ORCID 0000-0003-1869-6344
Kevin M StoffelDepartment of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.ORCID 0000-0003-1428-7471
Alexander A MerleevDepartment of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.
Shyam K MoreDivision of Gastroenterology, Department of Internal Medicine, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.
Emanual MaverakisDepartment of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.
Helen E RaybouldDepartment of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
Mingyi ChenDepartment of Pathology and Laboratory Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0001-6754-0480
Robert J CanterDivision of Surgical Oncology, Department of Surgery, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.ORCID 0000-0002-3331-5418
Arta M MonjazebDepartment of Radiation Oncology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.
Maneesh DaveDivision of Gastroenterology, Department of Internal Medicine, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.
James L M FerraraTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0001-8595-3940
John E LevineTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Dan L LongoDepartment of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Mehrdad AbediDepartment of Internal Medicine, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.ORCID 0000-0003-4640-0977
Bruce R BlazarMasonic Cancer Center and Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-9608-9841
William J MurphyDepartment of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA. wmjmurphy@ucdavis.edu.ORCID 0000-0002-2793-401X
University of California, Davis · USUniversity of Minnesota · USIcahn School of Medicine at Mount Sinai · USBiotechnology Institute · USHarvard University · USMacalester College · USSouthwestern Medical CenterUniversity of Minnesota Medical Center · US
Funding
Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Gina M Dayton · 2002 to 2026
$84.9MTrial Design and Biostatistical Support CoreP01CA065493 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI J SUNIL RAO · 1995 to 2026
$48.2MTUMOR VACCINES AND BONE MARROW TRANSPLANTATIONP01CA039542 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JAMES L. M. FERRARA · 1985 to 2026
$47.9MEnhancing Treg Therapeutic Efficacy in GVHDR01HL118979 · NHLBI · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, HIPPEN, KELI L · 2014 to 2025
$6.7MT-CELL TARGETING FOR GVHDR01HL056067 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BLAZAR, BRUCE R · 1995 to 2022
$5.4MIn Vivo Prevention of Murine GVHDR37AI034495 · NIAID · UNIVERSITY OF MINNESOTA · PI Bruce R Blazar · 2017 to 2026
$5.4MMouse Metabolic Phenotyping Center (MMPC) at UC DavisU24DK092993 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LLOYD, KC KENT · 2011 to 2015
$4.1MMultispecies Comparison of the Impact of Obesity on GVHD/GVTR01CA214048 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MURPHY, WILLIAM JOSEPH · 2017 to 2021
$3.2MExploiting the VISTA Pathway to Prevent Acute GVHD and Control Steroid Refractory DiseaseR01HL155114 · NHLBI · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, NOELLE, RANDOLPH J. · 2021 to 2024
$2.7MNovel immunosuppressive mechanism of human bone marrow mesenchymal stem cells in experimental Crohn’s diseaseK08DK110421 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DAVE, MANEESH · 2017 to 2023
$980kNCI NIH HHS P01 CA039542NCI NIH HHS P01 CA065493NCI NIH HHS P30 CA093373NCI NIH HHS R01 CA214048NHLBI NIH HHS R01 HL056067NHLBI NIH HHS R01 HL118979NHLBI NIH HHS R01 HL155114NIAID NIH HHS R37 AI034495NIDDK NIH HHS K08 DK110421NIDDK NIH HHS U24 DK092993
Abstract
The efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is limited by acute and chronic graft-versus-host disease (GVHD). The impact of obesity on allo-HSCT outcomes is poorly understood. Here, we report that obesity had a negative and selective impact on acute gut GVHD after allo-HSCT in mice with diet-induced obesity (DIO). These animals exhibited increased gut permeability, endotoxin translocation across the gut, and radiation-induced gastrointestinal damage after allo-HSCT. After allo-HSCT, both male and female DIO mouse recipients showed increased proinflammatory cytokine production and expression of the GVHD marker ST2 (IL-33R) and MHC class II molecules; they also exhibited decreased survival associated with acute severe gut GVHD. This rapid-onset, obesity-associated gut GVHD depended on donor CD4
Indexed as
Gastrointestinal MicrobiomeGraft vs Host DiseaseHematopoietic Stem Cell TransplantationAcute DiseaseAnimalsFemaleMaleMiceObesityRetrospective Studies
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