Evidence map›Paper›PMID 33239356›Full record

SynthesisBritish journal of sports medicine2020

Joint associations of accelero-meter measured physical activity and sedentary time with all-cause mortality: a harmonised meta-analysis in more than 44 000 middle-aged and older individuals.

Ulf Ekelund, Jakob Tarp, Morten W Fagerland, Jostein Steene Johannessen, Bjørge H Hansen, Barbara J Jefferis, Peter H Whincup, Keith M Diaz, Steven Hooker, Virginia J Howard and 13 more

Registry-linked trialOpen access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in British journal of sports medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06883591 (Physical Activity in Patients After Resurfacing and Total Hip Arthroplasty), which is not on this map. Cited by 166 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
166citing papers in PubMed, 16 pooled it
21.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06883591 completednot on this mapstarted 2025, after this paper: background citation

Physical Activity in Patients After Resurfacing and Total Hip Arthroplasty: an Observational Follow-up Study 15 Years After Surgery.

TypeobservationalSponsorRijnstate HospitalRan2025 to 2026Enrolled32ConditionsTotal Hip Arthroplasty (THA), Accelerometers, Resurfacing Hip Arthroplasty
3 · Its place in the literature

Who cites it

166 citing papers in PubMed, 16 syntheses or guidelines pooled it, 365 citations in OpenAlex.

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  16. Interventions for reducing sedentary behaviour in people with stroke.The Cochrane database of systematic reviews · 2021
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106 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 15 institutions in 7 countries.

Ulf EkelundDepartment of Sport Medicine, Norwegian School of Sport Sciences, Oslo, Norway Ulf.Ekelund@nih.no.ORCID http://orcid.org/0000-0003-2115-9267
Jakob TarpDepartment of Sport Medicine, Norwegian School of Sport Sciences, Oslo, Norway.
Morten W FagerlandDepartment of Sport Medicine, Norwegian School of Sport Sciences, Oslo, Norway.
Jostein Steene JohannessenDepartment of Sport Medicine, Norwegian School of Sport Sciences, Oslo, Norway.
Bjørge H HansenDepartment of Sport Medicine, Norwegian School of Sport Sciences, Oslo, Norway.
Barbara J JefferisPrimary Care & Population Health, Institute of Epidemiology & Health care, University College London, London, UK.
Peter H WhincupPopulation Health Research Institute, St George's, University of London, London, UK.
Keith M DiazCenter for Behavioral Cardiovascular Health, Columbia University Medical Center, New York, New York, USA.
Steven HookerCollege of Health and Human Services, San Diego State University, San Diego, California, USA.
Virginia J HowardDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Ariel ChernofskyDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Martin G LarsonDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Nicole SpartanoDepartment of Endocrinology, Diabetes, Nutrition and Weight Management, Boston University School of Medicine, Boston, Massachusetts, USA.
Ramachandran S VasanDepartments of Medicine and Epidemiology, Boston University School of Medicine and Boston University School of Public Health, Boston, Massachusetts, USA.
Ing-Mari DohrnDepartment of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-2593-550X
Maria HagströmerDepartment of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden.
Charlotte EdwardsonNIHR Leicester Biomedical Research Centre, University of Leicester and University Hospitals of Leicester NHS Trust, Leicester, UK.
Thomas YatesNIHR Leicester Biomedical Research Centre, University of Leicester and University Hospitals of Leicester NHS Trust, Leicester, UK.
Eric J ShiromaLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland, USA.
Paddy DempseyMedical Research Council Epidemiology Unit, University of Cambridge, Cambridge, Cambridgeshire, UK.
Katrien WijndaeleMedical Research Council Epidemiology Unit, University of Cambridge, Cambridge, Cambridgeshire, UK.
Sigmund A AnderssenDepartment of Sport Medicine, Norwegian School of Sport Sciences, Oslo, Norway.
I-Min LeeDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID http://orcid.org/0000-0002-1083-6907
Boston University · USNorwegian School of Sport Sciences · NOCentre College · USKarolinska Institutet · SEBaker Heart and Diabetes Institute · AUBrigham and Women's Hospital · USCentre de recherche en Epidémiologie et Santé des Populations · FRColumbia University Irving Medical Center · USNorwegian Institute of Public Health · NOSan Diego State University · USSt George's, University of London · GBUniversity College London · GBUniversity of Agder · NOUniversity of Alabama at Birmingham · USUniversity of Cambridge · GB

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
Women's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI W Timothy GARVEY · 2013 to 2026
$19.5M
Proteomic Profiling of Precise Exercise Pathophenotypes Across the HFpEF SpectrumR01HL131029 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Gregory Dyer Lewis, Matthew G. Nayor · 2016 to 2026
$7.7M
Women's Health Study: Continued Follow-UpR01HL080467 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E. · 2005 to 2010
$4.5M
Women's Health Study: Infrastructure support for continued cohort follow-upU01CA182913 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 2019 to 2023
$4.0M
The Women's Health Study: Infrastructure Support for Continued Cohort Follow-upUM1CA182913 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 2014 to 2018
$4.0M
Cardiometabolic Outcomes in Multi-ethnic Physical Activity & Sedentary Behavior Study (COMPASS)R01HL136266 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KAPLAN, ROBERT C, MOSSAVAR-RAHMANI, YASMIN · 2017 to 2020
$3.1M
Impact of Physical Activity on Stroke and Cognitive Function in Older AdultsR01NS061846 · NINDS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI HOOKER, STEVEN PAUL · 2008 to 2012
$2.9M
TRIAL OF VITAMIN E, BETA-CAROTENE &ASPRIN IN WOMENR01HL043851 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E · 1991 to 2000
$1.6M
Objectively Measured Physical Activity and Mortality in WomenR01CA154647 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI LEE, I-MIN · 2011 to 2014
$1.2M
The Women's Health Study: Addition of New Data to Maximize its Research ImpactRC1HL099355 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E. · 2009 to 2010
$992k
British Heart Foundation PG/13/86/30546British Heart Foundation RG/13/16/30528Cancer Research UK 14136Medical Research Council G0401527Medical Research Council G0500300Medical Research Council G1000143Medical Research Council MC_UU_00006/4Medical Research Council MC_UU_12015/3Medical Research Council MR/N003284/1NCI NIH HHS R01 CA047988NCI NIH HHS R01 CA154647NCI NIH HHS U01 CA182913NCI NIH HHS UM1 CA182913NHLBI NIH HHS N01 HC025195NHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL080467NHLBI NIH HHS R01 HL131029NHLBI NIH HHS R01 HL136266NHLBI NIH HHS RC1 HL099355NIA NIH HHS R01 AG047645NIDDK NIH HHS P30 DK079626NINDS NIH HHS R01 NS061846NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

objectivesTo examine the joint associations of accelerometer-measured physical activity and sedentary time with all-cause mortality.

methodsWe conducted a harmonised meta-analysis including nine prospective cohort studies from four countries. 44 370 men and women were followed for 4.0 to 14.5 years during which 3451 participants died (7.8% mortality rate). Associations between different combinations of moderate-to-vigorous intensity physical activity (MVPA) and sedentary time were analysed at study level using Cox proportional hazards regression analysis and summarised using random effects meta-analysis.

resultsAcross cohorts, the average time spent sedentary ranged from 8.5 hours/day to 10.5 hours/day and 8 min/day to 35 min/day for MVPA. Compared with the referent group (highest physical activity/lowest sedentary time), the risk of death increased with lower levels of MVPA and greater amounts of sedentary time. Among those in the highest third of MVPA, the risk of death was not statistically different from the referent for those in the middle (16%; 95% CI 0.87% to 1.54%) and highest (40%; 95% CI 0.87% to 2.26%) thirds of sedentary time. Those in the lowest third of MVPA had a greater risk of death in all combinations with sedentary time; 65% (95% CI 1.25% to 2.19%), 65% (95% CI 1.24% to 2.21%) and 263% (95% CI 1.93% to 3.57%), respectively.

conclusionHigher sedentary time is associated with higher mortality in less active individuals when measured by accelerometry. About 30-40 min of MVPA per day attenuate the association between sedentary time and risk of death, which is lower than previous estimates from self-reported data.

Indexed as

AccelerometryExerciseSedentary BehaviorAgedHumansMiddle AgedMortality, PrematureTime Factorsaccelerometerdeathmeta-analysissedentary

Identifiers

PMID33239356
PMCPMC7719907
OpenAlexW3108517679

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.