ArticleBMJ (Clinical research ed.)2020
Gestational age and hospital admissions during childhood: population based, record linkage study in England (TIGAR study).
Article in BMJ (Clinical research ed.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- An open-label, phase IV randomised controlled trial of two schedules of a four-component meningococcal B vaccine in UK preterm infants.Archives of disease in childhood · 2024Trial
- Capacity Planning for Small Hospitals and Departments Illustrated Using Maternity and Paediatrics Departments: Roles for Weighted Population Density, Seasonality and Size, Myths Around Length of Stay and Factors Influencing Costs and Funding.International journal of environmental research and public health · 2026Article
- Effect of transabdominal versus transvaginal cerclage on preterm birth and neonatal outcomes among patients with a history of cervical insufficiency.American journal of obstetrics and gynecology · 2026Article
- Prevalence, main diagnoses, and outcomes of hospital admissions in Mongolian children: a national registry-based descriptive analysis.Frontiers in pediatrics · 2026Article
- Timing of Term Births and Associated Mortality Risks: Ecological Analysis Across 28 European Countries.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Neonatal Morbidities and Hospitalization in the First 2 Years of Life Among Infants Born Very Preterm.JAMA network open · 2025Article
- Post-Discharge Trajectories of Romanian Premature Infants: A Cross-Sectional Analysis of Associated Factors.Children (Basel, Switzerland) · 2025Article
- Malaria morbidity, mortality and associated costs in Indonesia: analysis of the National Health Insurance claim dataset.BMJ global health · 2025Article
- Cervical elastography at 18 to 23 weeks to predict spontaneous preterm birth in individuals with a history of preterm birth.AJOG global reports · 2025Article
- Perinatal risk factors and preliminary prediction of conductive hearing loss in infancy.Journal of otology · 2025Article
- The Association Between Neighborhood Gunshot Frequency and the Development of Preterm Birth.Women's health reports (New Rochelle, N.Y.) · 2025Article
- Associations between maternal body mass index and childhood infections in UK primary care: findings from the Born in Bradford birth cohort study.Archives of disease in childhood · 2024Article
- Mortality from external causes in late adolescence and early adulthood by gestational age and sex: a population-based cohort study in four Nordic countries.BMC medicine · 2024Article
- Use of uterine electromyography in the prediction of preterm birth after transvaginal cervical cerclage.BMC pregnancy and childbirth · 2024Article
- Paediatric intensive care admissions of preterm children born <32 weeks gestation: a national retrospective cohort study using data linkage.Archives of disease in childhood. Fetal and neonatal edition · 2024Article
- Five-minute Apgar score and risk of neonatal mortality, severe neurological morbidity and severe non-neurological morbidity in term infants - an Australian population-based cohort study.The Lancet regional health. Western Pacific · 2024Article
- Maternal mitochondrial DNA copy number and methylation as possible predictors of pregnancy outcomes in a Michigan pregnancy cohort.Environmental epigenetics · 2024Article
- Short-term effects of air pollution exposure on the risk of preterm birth in Xi'an, China.Annals of medicine · 2023Article
- Prevalence and nature of prior developmental and medical concerns in toddlers who screen positive for autism in primary care.Autism : the international journal of research and practice · 2023Article
- Breastfeeding and impact on childhood hospital admissions: a nationwide birth cohort in South Korea.Nature communications · 2023Article
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Abstract
objectiveTo examine the association between gestational age at birth and hospital admissions to age 10 years and how admission rates change throughout childhood.
designPopulation based, record linkage, cohort study in England.
settingNHS hospitals in England, United Kingdom.
participants1 018 136 live, singleton births in NHS hospitals in England between January 2005 and December 2006.
main outcome measuresPrimary outcome was all inpatient hospital admissions from birth to age 10, death, or study end (March 2015); secondary outcome was the main cause of admission, which was defined as the World Health Organization's first international classification of diseases, version 10 (ICD-10) code within each hospital admission record.
results1 315 338 admissions occurred between 1 January 2005 and 31 March 2015, and 831 729 (63%) were emergency admissions. 525 039 (52%) of 1 018 136 children were admitted to hospital at least once during the study period. Hospital admissions during childhood were strongly associated with gestational age at birth (<28, 28-29, 30-31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, and 42 weeks). In comparison with children born at full term (40 weeks' gestation), those born extremely preterm (<28 weeks) had the highest rate of hospital admission throughout childhood (adjusted rate ratio 4.92, 95% confidence interval 4.58 to 5.30). Even children born at 38 weeks had a higher rate of hospital admission throughout childhood (1.19, 1.16 to 1.22). The association between gestational age and hospital admission decreased with increasing age (interaction P<0.001). Children born earlier than 28 weeks had an adjusted rate ratio of 6.34 (95% confidence interval 5.80 to 6.85) at age less than 1 year, declining to 3.28 (2.82 to 3.82) at ages 7-10, in comparison with those born full term; whereas in children born at 38 weeks, the adjusted rate ratios were 1.29 (1.27 to 1.31) and 1.16 (1.13 to 1.19), during infancy and ages 7-10, respectively. Infection was the main cause of excess hospital admissions at all ages, but particularly during infancy. Respiratory and gastrointestinal conditions also accounted for a large proportion of admissions during the first two years of life.
conclusionsThe association between gestational age and hospital admission rates decreased with age, but an excess risk remained throughout childhood, even among children born at 38 and 39 weeks of gestation. Strategies aimed at the prevention and management of childhood infections should target children born preterm and those born a few weeks early.
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