Evidence map›Paper›PMID 33239041›Full record

ArticleGlobalization and health2020

Early cases of SARS-CoV-2 infection in Uganda: epidemiology and lessons learned from risk-based testing approaches - March-April 2020.

Richard Migisha, Benon Kwesiga, Bernadette Basuta Mirembe, Geofrey Amanya, Steven N Kabwama, Daniel Kadobera, Lilian Bulage, Godfrey Nsereko, Ignatius Wadunde, Tonny Tindyebwa and 8 more

Open access · goldAbstract read
In one paragraph

Article in Globalization and health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Asymptomatic SARS-CoV-2 infection: A systematic review and meta-analysis.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Richard MigishaUganda Public Health Fellowship Program, Ministry of Health, Kampala, Uganda. rmigisha@musph.ac.ug.ORCID 0000-0003-1709-9521
Benon KwesigaUganda Public Health Fellowship Program, Ministry of Health, Kampala, Uganda.
Bernadette Basuta MirembeMinistry of Health, Kampala, Uganda.
Geofrey AmanyaUganda Public Health Fellowship Program, Ministry of Health, Kampala, Uganda.
Steven N KabwamaUganda Public Health Fellowship Program, Ministry of Health, Kampala, Uganda.
Daniel KadoberaUganda Public Health Fellowship Program, Ministry of Health, Kampala, Uganda.
Lilian BulageUganda Public Health Fellowship Program, Ministry of Health, Kampala, Uganda.
Godfrey NserekoMinistry of Health, Kampala, Uganda.
Ignatius WadundeUganda Public Health Fellowship Program, Ministry of Health, Kampala, Uganda.
Tonny TindyebwaMakerere University School of Public Health, Kampala, Uganda.
Bernard LubwamaMinistry of Health, Kampala, Uganda.
Atek A KagiritaMinistry of Health, Kampala, Uganda.
John T KayiwaUganda Virus Research Institute, Entebbe, Uganda.
Julius J LutwamaUganda Virus Research Institute, Entebbe, Uganda.
Amy L BooreUS Centers for Disease Control and Prevention, Kampala, Uganda.
Julie R HarrisUS Centers for Disease Control and Prevention, Kampala, Uganda.
Henry Kyobe BosaUganda Virus Research Institute, Entebbe, Uganda.
Alex Riolexus ArioUganda Public Health Fellowship Program, Ministry of Health, Kampala, Uganda.
Ministry of Health · UGUganda Virus Research Institute · UGCenters for Disease Control and Prevention · UGMakerere University · UG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOn March 13, 2020, Uganda instituted COVID-19 symptom screening at its international airport, isolation and SARS-CoV-2 testing for symptomatic persons, and mandatory 14-day quarantine and testing of persons traveling through or from high-risk countries. On March 21, 2020, Uganda reported its first SARS-CoV-2 infection in a symptomatic traveler from Dubai. By April 12, 2020, 54 cases and 1257 contacts were identified. We describe the epidemiological, clinical, and transmission characteristics of these cases.

methodsA confirmed case was laboratory-confirmed SARS-CoV-2 infection during March 21-April 12, 2020 in a resident of or traveler to Uganda. We reviewed case-person files and interviewed case-persons at isolation centers. We identified infected contacts from contact tracing records.

resultsMean case-person age was 35 (±16) years; 34 (63%) were male. Forty-five (83%) had recently traveled internationally ('imported cases'), five (9.3%) were known contacts of travelers, and four (7.4%) were community cases. Of the 45 imported cases, only one (2.2%) was symptomatic at entry. Among all case-persons, 29 (54%) were symptomatic at testing and five (9.3%) were pre-symptomatic. Among the 34 (63%) case-persons who were ever symptomatic, all had mild disease: 16 (47%) had fever, 13 (38%) reported headache, and 10 (29%) reported cough. Fifteen (28%) case-persons had underlying conditions, including three persons with HIV. An average of 31 contacts (range, 4-130) were identified per case-person. Five (10%) case-persons, all symptomatic, infected one contact each.

conclusionThe first 54 case-persons with SARS-CoV-2 infection in Uganda primarily comprised incoming air travelers with asymptomatic or mild disease. Disease would likely not have been detected in these persons without the targeted testing interventions implemented in Uganda. Transmission was low among symptomatic persons and nonexistent from asymptomatic persons. Routine, systematic screening of travelers and at-risk persons, and thorough contact tracing will be needed for Uganda to maintain epidemic control.

Indexed as

Contact TracingCOVID-19 TestingPandemicsTravelAdolescentAdultAgedChildComorbidityCoronavirus InfectionsCOVID-19FemaleHumansMaleMass ScreeningMiddle AgedCOVID-19EpidemiologySARS-Cov-2SurveillanceUganda

Identifiers

PMID33239041
PMCPMC7686950
OpenAlexW3109471713

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.