Evidence map›Paper›PMID 33239026›Full record

ArticleThe international journal of behavioral nutrition and physical activity2020

New global guidelines on sedentary behaviour and health for adults: broadening the behavioural targets.

Paddy C Dempsey, Stuart J H Biddle, Matthew P Buman, Sebastien Chastin, Ulf Ekelund, Christine M Friedenreich, Peter T Katzmarzyk, Michael F Leitzmann, Emmanuel Stamatakis, Hidde P van der Ploeg and 2 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of behavioral nutrition and physical activity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07229963 (Postprandial Cardiometabolic Effects of Interrupting Sedentary Behavior With Exercise of Varying Intensity in Healthy Overweight Adults), which is not on this map. Cited by 133 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
133citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07229963 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Postprandial Cardiometabolic Effects of Interrupting Sedentary Behavior With Exercise of Varying Intensity in Healthy Overweight Adults

TypeinterventionalSponsorHacettepe UniversityRan2025 to 2026Enrolled16ConditionsCardiovascular Risk Markers, Substrate Oxidation, Postprandial Metabolism, Exercise PhysiologyArmsAerobic Exercise Intervention, Sprint Exercise Intervention, Sedentary Behaviour Intervention
3 · Its place in the literature

Who cites it

133 citing papers in PubMed, 13 syntheses or guidelines pooled it.

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73 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Paddy C DempseyMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK. Paddy.Dempsey@mrc-epid.cam.ac.uk.ORCID 0000-0002-1714-6087
Stuart J H BiddleCentre for Health Research, University of Southern Queensland, Springfield Central, Australia.
Matthew P BumanCollege of Health Solutions, Arizona State University, Phoenix, AZ, USA.
Sebastien ChastinDepartment of Movement and Sports Sciences, University of Ghent, Ghent, Belgium.
Ulf EkelundDepartment of Sport Medicine, Norwegian School of Sport Science, Oslo, Norway.
Christine M FriedenreichDepartment of Cancer Epidemiology and Prevention Research, CancerControl Alberta, Alberta Health Services, Calgary, Canada.
Peter T KatzmarzykPennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.
Michael F LeitzmannDepartment of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
Emmanuel StamatakisCharles Perkins Centre, School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Hidde P van der PloegDepartment of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam University Medical Centres, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Juana WillumsenPhysical Activity Unit, Department of Health Promotion, World Health Organization, Geneva, Switzerland.
Fiona BullPhysical Activity Unit, Department of Health Promotion, World Health Organization, Geneva, Switzerland.

Funding

Medical Research Council MC_UU_12015/3
6 · The paper itself

Abstract

backgroundIn 2018, the World Health Organisation (WHO) commenced a program of work to update the 2010 Global Recommendations on Physical Activity for Health, for the first-time providing population-based guidelines on sedentary behaviour. This paper briefly summarizes and highlights the scientific evidence behind the new sedentary behaviour guidelines for all adults and discusses its strengths and limitations, including evidence gaps/research needs and potential implications for public health practice.

methodsAn overview of the scope and methods used to update the evidence is provided, along with quality assessment and grading methods for the eligible new systematic reviews. The literature search update was conducted for WHO by an external team and reviewers used the AMSTAR 2 (Assessment of Multiple Systematic Reviews) tool for critical appraisal of the systematic reviews under consideration for inclusion. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) method was used to rate the certainty (i.e. very low to high) of the evidence.

resultsThe updated systematic review identified 22 new reviews published from 2017 up to August 2019, 14 of which were incorporated into the final evidence profiles. Overall, there was moderate certainty evidence that higher amounts of sedentary behaviour increase the risk for all-cause, cardiovascular disease (CVD) and cancer mortality, as well as incidence of CVD, cancer, and type 2 diabetes. However, evidence was deemed insufficient at present to set quantified (time-based) recommendations for sedentary time. Moderate certainty evidence also showed that associations between sedentary behaviour and all-cause, CVD and cancer mortality vary by level of moderate-to-vigorous physical activity (MVPA), which underpinned additional guidance around MVPA in the context of high sedentary time. Finally, there was insufficient or low-certainty systematic review evidence on the type or domain of sedentary behaviour, or the frequency and/or duration of bouts or breaks in sedentary behaviour, to make specific recommendations for the health outcomes examined.

conclusionsThe WHO 2020 guidelines are based on the latest evidence on sedentary behaviour and health, along with interactions between sedentary behaviour and MVPA, and support implementing public health programmes and policies aimed at increasing MVPA and limiting sedentary behaviour. Important evidence gaps and research opportunities are identified.

Indexed as

Guidelines as TopicSedentary BehaviorSystematic Reviews as TopicWorld Health OrganizationAdultCardiovascular DiseasesDiabetes Mellitus, Type 2ExerciseHumansNeoplasmsPolicyPublic HealthRisk FactorsCancerCardiovascularChronic diseaseExerciseGlobal healthGuidelinesHealth promotionPhysical activityPublic healthSedentaryType 2 diabetes

Identifiers

PMID33239026
PMCPMC7691115

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.