ArticleBMC complementary medicine and therapies2020
Anticancer activity of Momordica cochinchinensis (red gac) aril and the impact of varietal diversity.
Article in BMC complementary medicine and therapies, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Hepatoprotective Effects of Gac (Journal of experimental pharmacology · 2025Article
- Impact of foam-mat drying conditions of "Gấc" aril on drying rate and bioactive compounds: Optimization by novel statistical approaches.Food chemistry: X · 2024Article
- Momordica cochinchinensis (Gac) Aril Suppresses Proliferation and Induces Apoptosis of Colorectal Cancer Cells.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- The Inhibitory Effect of KerraMedicina (Kaunas, Lithuania) · 2023Article
- Anticancer and Antimutagenic Properties ofWorld journal of oncology · 2023Article
- Exploring the Apoptotic-Induced Biochemical Mechanism of Traditional Thai Herb (Kerra™) Extract in HCT116 Cells Using a Label-Free Proteomics Approach.Medicina (Kaunas, Lithuania) · 2023Article
- Article
- Stem Extract fromMolecules (Basel, Switzerland) · 2022Article
- Sonicated Extract from the Aril ofJournal of toxicology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMomordica cochinchinensis (Cucurbitaceae) is a nutritionally and medicinally important fruit restricted to South East Asia with diverse morphological and genetic variations but there is limited information on its medicinal potential.
methodsM. cochinchinensis aril from 44 different samples in Australia, Thailand and Vietnam were extracted using different solvents and tested for its anticancer potential. Anticancer activity of M. cochinchinensis aril on breast cancer (MCF7 and BT474) and melanoma (MM418C1 and D24) cells were compared to control fibroblasts (NHDF). The cytotoxicity of the cells following treatment with the aril extract was determined using CCK-8 assay. Biochemical and morphological changes were analysed using flow cytometry, confocal and transmission electron microscopy to determine the mechanism of cell death.
resultsThe water extract from the aril of M. cochinchinensis elicited significantly higher cytotoxicity towards breast cancer and melanoma cells than the HAE extract. The IC
conclusionsThe water extract of M. cochinchinensis aril caused significant apoptosis and necrosis of breast cancer and melanoma cells, with varieties from Northern Vietnam possessing superior activity. This highlights the potential of this fruit in the development of novel anticancer agents against such tumours, with specific regions on where to collect the best variety and extraction solvent for optimum activity.
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