ArticleBMC infectious diseases2020
Clinical characteristics of Epstein-Barr virus infection in the pediatric nervous system.
Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Epidemiology and etiology of brain cancer in Africa: A systematic review.Brain and behavior · 2023Pooled it
- Review
- Adult Epstein-Barr virus encephalitis: a retrospective case report series with metagenomic next-generation sequencing-based diagnosis.Frontiers in neurology · 2026Article
- Possible Epstein-Barr virus-associated central nervous system involvement with reversible electroencephalographic abnormalities in a child: a case report.AME case reports · 2026Article
- Prognostic scoring model incorporating clinical characteristics for pediatric hemophagocytic lymphohistiocytosis: a multicenter retrospective study.Annals of hematology · 2025Article
- Novel Perspectives Focused on the Relationship Between Herpesvirus Encephalitis and Anti-GFAP-Antibody-Positive Astrocytopathy.Molecular neurobiology · 2025Review
- Clinical Features and Laboratory Findings of Hospitalized Children with Infectious Mononucleosis Caused by Epstein-Barr Virus from Croatia.Pathogens (Basel, Switzerland) · 2025Article
- Cytotoxic Lesions of the Corpus Callosum (CLOCCs) in a Patient with Epstein-Barr Infection: A Case Report and Literature Review.Brain sciences · 2025Article
- Fatal Fulminant Epstein-Barr Virus (EBV) Encephalitis in Immunocompetent 5.5-Year-Old Girl-A Case Report with the Review of Diagnostic and Management Dilemmas.Biomedicines · 2024Article
- Epstein-Barr Virus encephalitis associated hemophagocytic lymphohistiocytosis in childhood-onset systemic lupus erythematosus: a case-based review.Pediatric rheumatology online journal · 2024Review
- Rare Co-occurrence of Spinal Cord Hemorrhage from Radiation-induced Cavernous Hemangioma and Classical Hodgkin Lymphoma Post-transplant Lymphoproliferative Disorder.Internal medicine (Tokyo, Japan) · 2024Article
- Article
- Liver injury and prolonged hospitalization as indicators of severity in patients with adenovirus infections.BMC infectious diseases · 2024Article
- Understanding the Neurotrophic Virus Mechanisms and Their Potential Effect on Systemic Lupus Erythematosus Development.Brain sciences · 2024Review
- Autoimmune encephalitis followed by hemophagocytic lymph histiocytosis: a case report.Frontiers in immunology · 2024Article
- Characterizing Epstein-Barr virus infection of the central nervous system in Zambian adults living with HIV.Journal of neurovirology · 2023Article
- Epstein-Barr Virus Encephalitis: A Review of Case Reports from the Last 25 Years.Microorganisms · 2023Review
- Spectrum of neuroradiological manifestations in primary hemophagocytic lymphohistiocytosis: a comparative study of EBV-induced versus non-EBV-induced forms in 75 genetically confirmed pediatric cases.European radiology · 2023Article
- Unilateral hypoglossal nerve palsy following orthognathic surgery: A case report and literature review.International journal of surgery case reports · 2023Article
- Unpacking the CNS Manifestations of Epstein-Barr Virus: An Imaging Perspective.AJNR. American journal of neuroradiology · 2023Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate the clinical characteristics of Epstein-Barr virus (EBV) infection in the pediatric nervous system (NS).
methodsWe retrospectively analyzed the clinical data and follow-up results of 89 children with neurological damage caused by EBV who were hospitalized in the children's hospital of Chongqing Medical University from January 2008 to April 2019.
resultsEBV infection of the NS can occur at any time of the year. The highest incidence was seen in the age group of 0-4 years. Fever is the main clinical feature (74/89, 83.1%). The main clinical types were encephalitis/meningoencephalitis (64/89, 71.9%), acute myelitis (2/89, 2.2%), acute disseminated encephalomyelitis (ADEM) (3/89, 3.4%), Guillain-Barré Syndrome (GBS) (15/89, 16.9%), neurological damage caused by EBV-hemophagocytic lymphohistiocytosis (EBV-HLH) (4/89, 4.5%), and NS-post-transplant lymphoproliferative disorder (NS-PTLD) (1/89, 1.1%). Anti-N-methyl-D-aspartate receptor encephalitis was found during the convalescence of EBV encephalitis. EBV encephalitis/meningitis showed no symptoms of tonsillitis, lymph node enlargement, skin rash, hepatosplenomegaly. Acute motor axonal neuropathy is the chief complication in GBS caused by EBV.
conclusionThere were significant differences in neurological complications caused by EBV. The prognosis of EBV infection in the NS is generally good. These illnesses are often self-limiting. A few cases may show residual sequelae.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.