Evidence map›Paper›PMID 33238903›Full record

ArticleBMC infectious diseases2020

High rates of multi-drug resistant gram-negative organisms associated with surgical site infections in a teaching hospital in Ghana.

Antoinette A A Bediako-Bowan, Jørgen A L Kurtzhals, Kåre Mølbak, Appiah-Korang Labi, Enid Owusu, Mercy J Newman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.

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  15. Carbapenem-ResistantCase reports in infectious diseases · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Antoinette A A Bediako-BowanDepartment of Surgery, University of Ghana Medical School, University of Ghana, P. O. Box 4356, Accra, Ghana. abediako-bowan@ug.edu.gh.ORCID http://orcid.org/0000-0002-9725-1839
Jørgen A L KurtzhalsCentre for Medical Parasitology at Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Kåre MølbakDepartment of Veterinary and Animal Science, University of Copenhagen, Copenhagen, Denmark.
Appiah-Korang LabiCentre for Medical Parasitology at Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Enid OwusuDepartment of Medical Laboratory Sciences, School of Biomedical and Allied Health Science, University of Ghana, Legon, Accra, Ghana.
Mercy J NewmanDepartment of Medical Microbiology, University of Ghana Medical School, University of Ghana, Accra, Ghana.
Statens Serum Institut · DKUniversity of Copenhagen · DKUniversity of Ghana · GH

Funding

Danish International Development Agency 16-PO1-GHA
6 · The paper itself

Abstract

backgroundThere is limited data to guide the prevention and management of surgical site infections (SSI) in low- and middle-income countries. We prospectively studied aetiological agents associated with SSI and their corresponding antibiotic susceptibility patterns in a tertiary hospital in Ghana.

methodsAs part of a cohort study carried out at the surgical department of the Korle Bu Teaching Hospital (KBTH) from July 2017 to April 2019, wound swabs were collected from patients diagnosed with SSI. Isolates cultured from the wound swabs were identified by MALDI TOF and susceptibility testing was conducted according to EUCAST 2020 guidelines. Clinical data were monitored prospectively.

resultsOf 4577 patients, 438 developed an SSI and 352 microbial isolates were cultured. Isolates were predominantly Gram negative (286, 81%), a pattern seen for all kinds of surgery and all wound classes. The most common species included Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus and Acinetobacter baumannii. The majority of organisms were multi-drug resistant including 86% of E. coli, 52% of A. baumannii and 86% of K. pneumoniae; and 65% (17/26) of the cefotaxime-resistant K. pneumoniae were extended spectrum β-lactamase producing. One of 139 E. coli, 15 of 49 P. aeruginosa, and 6 of 23 A. baumannii were meropenem resistant, but no clonal pattern was found. There was a 1% (5/428) prevalence of methicillin-resistant S. aureus.

conclusionsThe predominance of Gram-negative organisms and the high level of multi-drug resistance indicate a need to re-evaluate antibiotic prophylaxis and treatment protocols in surgical practice in low- and middle-income countries.

Indexed as

AdultAnti-Bacterial AgentsAntibiotic ProphylaxisDrug Resistance, Multiple, BacterialFemaleGhanaGram-Negative BacteriaGram-Negative Bacterial InfectionsHospitals, TeachingHumansMaleMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMiddle AgedProspective StudiesStaphylococcal InfectionsAnti-Bacterial AgentsESBLGhanaGram-negative organismsMultidrug resistantSurgical site infection

Identifiers

PMID33238903
PMCPMC7689982
OpenAlexW3107724607

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.