Evidence map›Paper›PMID 33238655›Full record

ArticleBiomolecules2020

Sirt1 Activity in PBMCs as a Biomarker of Different Heart Failure Phenotypes.

Valeria Conti, Graziamaria Corbi, Maria Vincenza Polito, Michele Ciccarelli, Valentina Manzo, Martina Torsiello, Emanuela De Bellis, Federica D'Auria, Gennaro Vitulano, Federico Piscione and 5 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
8.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 85 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Valeria ContiDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.
Graziamaria CorbiDepartment of Medicine and Health Sciences, University of Molise, 86100 Campobasso, Italy.ORCID 0000-0002-3441-889X
Maria Vincenza PolitoDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.
Michele CiccarelliDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.ORCID 0000-0003-2379-1960
Valentina ManzoDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.ORCID 0000-0002-4521-0453
Martina TorsielloDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.
Emanuela De BellisDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.
Federica D'AuriaDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.
Gennaro VitulanoDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.
Federico PiscioneDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.
Albino CarrizzoDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.
Paola Di PietroDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.ORCID 0000-0003-1327-1961
Carmine VecchioneDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.
Nicola FerraraDepartment of Translational Medical Sciences, Federico II University of Naples, 80131 Naples, Italy.ORCID 0000-0001-8200-4942
Amelia FilippelliDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.ORCID 0000-0002-8235-9118
University of Salerno · ITIstituti Clinici Scientifici Maugeri · ITUniversity of Molise · IT

Funding

Università degli Studi di Salerno ORSA153180 to Valeria Conti
6 · The paper itself

Abstract

Heart Failure (HF) is a syndrome, which implies the existence of different phenotypes. The new categorization includes patients with preserved ejection fraction (HFpEF), mid-range EF (HFmrEF), and reduced EF (HFrEF) but the molecular mechanisms involved in these HF phenotypes have not yet been exhaustively investigated. Sirt1 plays a crucial role in biological processes strongly related to HF. This study aimed to evaluate whether Sirt1 activity was correlated with EF and other parameters in HFpEF, HFmrEF, and HFrEF. Seventy patients, HFpEF (

Indexed as

AdultAgedAged, 80 and overAngiotensin-Converting Enzyme 2BiomarkersFemaleHeart FailureHumansLeukocytes, MononuclearMaleMiddle AgedNatriuretic Peptide, BrainSirtuin 1Stroke VolumeTumor Necrosis Factor-alphaACE2 protein, humanAngiotensin-Converting Enzyme 2BiomarkersNatriuretic Peptide, BrainSIRT1 protein, humanSirtuin 1TNF protein, humanTumor Necrosis Factor-alphaheart failure with mid-range ejection fractionheart failure with preserved ejection fractionheart failure with reduced ejection fractionSirt1sirtuins

Identifiers

PMID33238655
PMCPMC7700185
OpenAlexW3109366237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.