ArticleNutrients2020
Iron Status is Associated with Mood, Cognition, and Functional Ability in Older Adults: A Cross-Sectional Study.
Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Chronic Cerebral Hypoxia and Cognitive Impairment: A Systematic Review and Meta-Analysis Based on Chronic Mountain Sickness, Anemia, Chronic Obstructive Pulmonary Disease, and Obstructive Sleep Apnea.CNS neuroscience & therapeutics · 2026Pooled it
- Prevalence of iron deficiency in patients admitted to a geriatric unit: a multicenter cross-sectional study.BMC geriatrics · 2024Trial
- The role of zinc homeostasis in major depressive disorder: heterogeneous pathological mechanisms and therapeutic implications.Annals of medicine · 2026Review
- Iron recovery dynamics after whole blood donation and the effect of low-dose iron supplementation in Japanese donors.Vox sanguinis · 2026Article
- Sex- and Age-Specific Inverted U-Shaped Links between Dietary Iron Intake and Serum α‑Klotho in Chinese Adults.Biological trace element research · 2026Article
- Association between ultra-processed foods intake and sleep quality/quantity in community-dwelling older adults.Sleep & breathing = Schlaf & Atmung · 2026Article
- Association between abdominal muscle mass quantified by computed tomography and depression in middle-aged and older Korean men: a cross-sectional study of 2,877 cases.Frontiers in medicine · 2026Article
- Iron deficiency and depression: evidence of critical risk periods.Frontiers in psychiatry · 2026Article
- Mechanism and regulation of iron absorption throughout the life cycle.Journal of advanced research · 2025Review
- Effects of pearl millet diet on serum micronutrient status, mental health and meta-cognitive skills in athletes: a randomised controlled trial.Discover mental health · 2025Article
- Analysis of the Correlation Between Depression-like Behaviors and Lipid Peroxidation in the Prefrontal Cortex of Mice: The Impact of Early Life Stress.Brain sciences · 2025Article
- Epidemiology and treatment of patients with iron deficiency and iron deficiency anemia: a study on longitudinal German health claims data.BMC public health · 2025Article
- Plant-Derived Nutraceuticals in Mental Health and Brain Function: Mechanisms of Action and Therapeutic Potential.International journal of molecular sciences · 2025Review
- Causality effect of 21 metals in plasma and serum, 731 immunocytes, and schizophrenia: an intermediary Mendelian randomization study in East Asian populations.Comprehensive psychoneuroendocrinology · 2025Article
- Abnormalities of lipid metabolism in the progression and treatment of depression.Frontiers in psychiatry · 2025Review
- Relationship between hemoglobin and grip strength in older adults: the ActiFE study.Aging clinical and experimental research · 2024Article
- Metal ions in biomedically relevant macromolecular structures.Frontiers in chemistry · 2024Review
- Iron deficiency and cognitive functioning in kidney transplant recipients: findings of the TransplantLines biobank and cohort study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023Article
- Appropriate Macronutrients or Mineral Elements Are Beneficial to Improve Depression and Reduce the Risk of Depression.International journal of molecular sciences · 2023Review
- Long-term trends in the consumption of sugary and diet soft drinks among adolescents: a cross-national survey in 21 European countries.European journal of nutrition · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Several conditions are risk factors for iron deficiency (ID), some of which are highly prevalent in older individuals. Despite the amount of evidence pointing for a role of ID in cognition, mood and physical functional ability, the research addressing these associations in older individuals is still scarce. In the present study, 162 older community-dwelling individuals (29.53% classified as ID) were enrolled in a cross-sectional analysis and characterized regarding cognition, mood, functional ability, general nutritional intake and iron status. Assessment of iron status was performed using several blood biomarkers. Storage and erythropoiesis dimensions were positively associated with memory, along with an interaction (moderator effect) between iron storage and nutritional status. A more depressed mood was negatively associated with (iron) transport, transport saturation and erythropoiesis dimensions, and functional tiredness was positively associated with the erythropoiesis dimension. These observations indicate that lower iron status is associated with depressive mood, functional tiredness and poorer memory ability, with the latter moderated by nutritional status. These findings suggest that using iron as a continuous variable may be useful in finding associations with iron homeostasis, eventually missed when iron levels are considered within the usual classification groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.