SynthesisInternational journal of environmental research and public health2020
Multimorbidity, Loneliness, and Social Isolation. A Systematic Review.
Synthesis in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05264207 (Nursing Students' Visits to Older Adults With Multiple Chronic Conditions), which is not on this map. Cited by 52 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nursing Students' Visits to Older Adults With Multiple Chronic Conditions: Effects on Self-care and Other Related Variables (VISITAME)
Who cites it
52 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Loneliness among adults at the end of life: A systematic review of prevalence and correlates.Palliative medicine · 2026Pooled it
- Pet's influence on humans' daily physical activity and mental health: a meta-analysis.Frontiers in public health · 2023Pooled it
- Informal Caregiving, Loneliness and Social Isolation: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Trial
- Chronic disease and social isolation among Canadians: evidence from the 2022 Mental Health and Access to Care Survey.Health promotion and chronic disease prevention in Canada : research, policy and practice · 2026Article
- Time toxicity in chronic disease comorbidity care: A concept analysis using Walker and Avant's approach.International journal of nursing sciences · 2026Article
- Loneliness among older adults with multiple chronic conditions: Exploring disparities for Hispanic adults in the 2023 Behavioral Risk Factor Surveillance System.Public health · 2026Observational
- Association of loneliness and perceived social exclusion with donation behavior among community-dwelling individuals aged 40 and over: longitudinal evidence from the nationally representative German Ageing Survey.Aging clinical and experimental research · 2026Observational
- The impact of leisure activities, dietary diversity, and BMI on physical-psychological-cognitive multimorbidity in elderly: a cross-sectional study.BMC public health · 2026Article
- Global trends and the case of China in Cardio-Kidney-Metabolic multimorbidity: development and validation of a composite risk index using GBD 1990-2021 data.Journal of health, population, and nutrition · 2026Article
- Beyond words: the association of hugging with loneliness, social isolation, and social withdrawal. Evidence from the general adult population in Germany based on a cross-sectional survey.Frontiers in public health · 2026Article
- How Is One's Own and (Ex-)Partner's Professional Prestige Associated With Loneliness and Isolation? Findings Based on Cross-Sectional Data From Middle-Aged and Older Adults Living in Germany in 2022/2023.Health science reports · 2025Article
- Meaning in life: bidirectional relationship with depression, anxiety, and loneliness in a longitudinal cohort of older primary care patients with multimorbidity.BMC geriatrics · 2025Article
- Assessment of Quality of Life in Lithuanian Patients with Multimorbidity Using the EQ-5D-5L Questionnaire.Medicina (Kaunas, Lithuania) · 2025Article
- Multicomponent telerehabilitation programme for older veterans with multimorbidity: a programme evaluation.BMJ military health · 2025Article
- Creative Aging: Unraveling the Psychosocial Benefits of Art Among Germany's Oldest Old. Findings From the Nationally Representative Study "Old Age in Germany (D80+)".International journal of geriatric psychiatry · 2025Article
- Associations Between Loneliness, Epigenetic Aging, and Multimorbidity Through Older Adulthood.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- [Migration background and loneliness among middle-aged and older adults in Germany].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2024Article
- Loneliness, epigenetic age acceleration, and chronic health conditions.Psychology and aging · 2024Article
- Prevalence and determinants of loneliness among the oldest old living in institutionalized settings : Study findings from a representative survey.Zeitschrift fur Gerontologie und Geriatrie · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
No systematic review has appeared so far synthesizing the evidence regarding multimorbidity and loneliness, social isolation, or social frailty. Consequently, our aim was to fill this gap. Three electronic databases (PubMed, PsycINFO, and CINAHL) were searched in our study. Observational studies examining the link between multimorbidity and loneliness, social isolation, and social frailty were included, whereas disease-specific samples were excluded. Data extraction included methods, characteristics of the sample, and the main results. A quality assessment was conducted. Two reviewers performed the study selection, data extraction, and quality assessment. In sum, eight studies were included in the final synthesis. Some cross-sectional and longitudinal studies point to an association between multimorbidity and increased levels of loneliness. However, the associations between multimorbidity and social isolation as well as social frailty remain largely underexplored. The quality of the studies included was rather high. In conclusion, most of the included studies showed a link between multimorbidity and increased loneliness. However, there is a lack of studies examining the association between multimorbidity and social isolation as well as social frailty. Future studies are required to shed light on these important associations. This is particularly important in times of the COVID-19 pandemic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.