SynthesisEndocrinology and metabolism (Seoul, Korea)2020
The Association of Overt and Subclinical Hyperthyroidism with the Risk of Cardiovascular Events and Cardiovascular Mortality: Meta-Analysis and Systematic Review of Cohort Studies.
Synthesis in Endocrinology and metabolism (Seoul, Korea), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Effects of Treatment with L-Thyroxine on Chronic Urticaria in Subjects with Autoimmune Thyroiditis: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2026Pooled it
- Platelet abnormalities in autoimmune thyroid diseases: A systematic review and meta-analysis.Frontiers in immunology · 2022Pooled it
- Impact of sleep restriction on biomarkers of thyroid function: Two pooled randomized trials.Sleep medicine · 2024Trial
- Thyroid dysfunction and cardiovascular disease.European heart journal · 2026Review
- Aescin and rutin mitigate hyperthyroidism-induced multisystem dysfunction via antioxidant and anti-inflammatory mechanisms in a rat model.Scientific reports · 2026Article
- Rethinking strategies for solving thyroid dysfunction at the heart of cardiovascular disease.Molecular medicine (Cambridge, Mass.) · 2025Review
- Prolonged Normal Thyroid Function AfterJournal of clinical medicine · 2025Article
- Article
- Cardiomyopathies of endocrine origin: A state-of-the-art review.World journal of cardiology · 2025Review
- Increased risk of multisystem comorbidities and disease trajectories following hyperthyroidism: evidence from the 0.5 million UK Biobank population.Endocrine connections · 2025Article
- Low Thyrotropin Levels Are Associated With an Increased Risk of Atherosclerotic Cardiovascular Disease in Euthyroid Individuals: The Korea National Health and Nutrition Examination Survey 2013-2015.Journal of lipid and atherosclerosis · 2025Article
- Establishing the TSH reference intervals for healthy adults aged over 70 years: the Australian ASPREE cohort study.Clinical chemistry and laboratory medicine · 2025Article
- The impact of thyroid disorder on cardiovascular disease: Unraveling the connection and implications for patient care.International journal of cardiology. Heart & vasculature · 2024Review
- Treatment of subclinical hyperthyroidism in patients older than 50 years: A randomized controlled study.European thyroid journal · 2024Article
- Magnitude of cardiac abnormality and its associated factors among hyperthyroidism patients on follow-up at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia.BMC cardiovascular disorders · 2024Article
- Zinc and Ferritin Levels and Their Associations with Functional Disorders and/or Thyroid Autoimmunity: A Population-Based Case-Control Study.International journal of molecular sciences · 2024Article
- Risks of suboptimal and excessive thyroid hormone replacement across ages.Journal of endocrinological investigation · 2024Review
- Article
- Thyroid and cardiovascular diseases.Turkish journal of medical sciences · 2024Review
- Association between atherosclerosis and the development of multi-organ pathologies.SAGE open medicine · 2024Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWhether hyperthyroidism is an independent risk factor for cardiovascular events remains controversial. We aimed to evaluate the association of overt and subclinical hyperthyroidism with the risk of ischemic heart disease (IHD), stroke, heart failure, and cardiovascular mortality.
methodsStudies regarding the association between hyperthyroidism and cardiovascular events were searched on PubMed and Embase databases. The cardiovascular disease (CVD) risk was classified as high and low, based on pre-existing diseases, including history of coronary, cerebral, or peripheral artery disease; heart failure; atrial fibrillation; diabetes mellitus; or chronic kidney disease.
resultsThirty-seven cohort studies were included in this meta-analysis. The pooled hazard ratio for subjects with overt hyperthyroidism compared with the control group was 1.11 (95% confidence interval [CI], 1.03 to 1.19) for IHD, 1.35 (95% CI, 1.03 to 1.75) for stroke, and 1.20 (95% CI, 1.00 to 1.46) for cardiovascular mortality. For subjects with subclinical hyperthyroidism, the pooled hazard ratio was 1.24 (95% CI, 1.07 to 1.45) for IHD, when compared with the control group. Subgroup analysis by CVD risk showed that the risk of stroke in overt hyperthyroidism was increased in the low CVD risk group; however, these association was not observed in the high CVD risk group. Similarly, the risk of IHD in subjects with subclinical hyperthyroidism was significantly increased in the low CVD risk group.
conclusionOvert hyperthyroidism is associated with increased risk of IHD, stroke, and cardiovascular mortality, and subclinical hyperthyroidism is associated with increased risk of IHD. These associations were particularly observed in the low risk CVD group without underlying CVD.
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Registered trials
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