ArticleCurrent biology : CB2021
A Paradoxical Kind of Sleep in Drosophila melanogaster.
Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 99 citations in OpenAlex.
- The Sentinel Sleep Theory: Unweaving the biological function of REM sleep.Sleep medicine: X · 2026Article
- Invertebrate brains as diversified models for understanding sleep mechanisms and function.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- Eye movement kinematics reveal novel circadian organization of sleep substates.Nature communications · 2026Article
- A day sleep promoting role of phototransduction inNeurobiology of sleep and circadian rhythms · 2026Article
- Zebrafish sleep displays distinct sub-states.iScience · 2026Article
- Recognition of distinct sleep states in Drosophila uncovers previously obscured homeostatic and circadian control of sleep.Current biology : CB · 2026Article
- Inferring the genetic basis of sleep states inbioRxiv : the preprint server for biology · 2026Article
- Characteristics of the sleep structure in the cleaner wrasse Labroides dimidiatus.Zoological letters · 2026Article
- DNA damage modulates sleep drive in basal cnidarians with divergent chronotypes.Nature communications · 2026Article
- Looking back: tracing the origins of sleep across the animal kingdom.Frontiers in neuroscience · 2026Review
- Current Evidence for Sleep States inCurrent sleep medicine reports · 2026Review
- Recognition of distinct sleep states inbioRxiv : the preprint server for biology · 2025Article
- The exploration of consciousness in insects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Zebrafish sleep displays distinct sub-states.bioRxiv : the preprint server for biology · 2025Article
- Article
- Long-term multichannel recordings in Drosophila flies reveal altered predictive processing during sleep compared with wake.The Journal of experimental biology · 2025Article
- Dynamics of glia and neurons regulate homeostatic rest, sleep and feeding behavior in Drosophila.Nature neuroscience · 2025Article
- FlyVISTA, an integrated machine learning platform for deep phenotyping of sleep inScience advances · 2025Article
- The dorsal fan-shaped body is a neurochemically heterogeneous sleep-regulating center in Drosophila.PLoS biology · 2025Article
- The effect of group size on sleep in a neotropical bat, Artibeus jamaicensis.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2024Article
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8 authors at 2 institutions in 3 countries.
Funding
Abstract
The dynamic nature of sleep in many animals suggests distinct stages that serve different functions. Genetic sleep induction methods in animal models provide a powerful way to disambiguate these stages and functions, although behavioral methods alone are insufficient to accurately identify what kind of sleep is being engaged. In Drosophila, activation of the dorsal fan-shaped body (dFB) promotes sleep, but it remains unclear what kind of sleep this is, how the rest of the fly brain is behaving, or if any specific sleep functions are being achieved. Here, we developed a method to record calcium activity from thousands of neurons across a volume of the fly brain during spontaneous sleep and compared this to dFB-induced sleep. We found that spontaneous sleep typically transitions from an active "wake-like" stage to a less active stage. In contrast, optogenetic activation of the dFB promotes sustained wake-like levels of neural activity even though flies become unresponsive to mechanical stimuli. When we probed flies with salient visual stimuli, we found that the activity of visually responsive neurons in the central brain was blocked by transient dFB activation, confirming an acute disconnect from the external environment. Prolonged optogenetic dFB activation nevertheless achieved a key sleep function by correcting visual attention defects brought on by sleep deprivation. These results suggest that dFB activation promotes a distinct form of sleep in Drosophila, where brain activity appears similar to wakefulness, but responsiveness to external sensory stimuli is profoundly suppressed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.