Evidence map›Paper›PMID 33238069›Full record

ArticleChembiochem : a European journal of chemical biology2021

A Cyanine-Bridged Somatostatin Hybrid Probe for Multimodal SSTR2 Imaging in Vitro and in Vivo: Synthesis and Evaluation.

Isabelle Heing-Becker, Carsten Grötzinger, Nicola Beindorff, Sonal Prasad, Sarah Erdmann, Samantha Exner, Rainer Haag, Kai Licha

Open access · hybridAbstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Unraveling the Chemistry ofACS bio & med chem Au · 2022
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Isabelle Heing-BeckerInstitut für Chemie und Biochemie, Freie Universität Berlin, Takustr. 3, 14195, Berlin, Germany.
Carsten GrötzingerDepartment of Hepatology and Gastroenterology, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Nicola BeindorffBERIC - Berlin Experimental Radionuclide Imaging Center, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Sonal PrasadBERIC - Berlin Experimental Radionuclide Imaging Center, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Sarah ErdmannDepartment of Hepatology and Gastroenterology, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Samantha ExnerDepartment of Hepatology and Gastroenterology, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Rainer HaagInstitut für Chemie und Biochemie, Freie Universität Berlin, Takustr. 3, 14195, Berlin, Germany.
Kai LichaInstitut für Chemie und Biochemie, Freie Universität Berlin, Takustr. 3, 14195, Berlin, Germany.ORCID 0000-0003-0907-0390
Charité - Universitätsmedizin Berlin · DEFreie Universität Berlin · DE

Funding

Dahlem Research SchoolDeutsche ForschungsgemeinschaftStudienstiftung des Deutschen Volkes
6 · The paper itself

Abstract

Multimodal imaging probes have attracted the interest of ongoing research, for example, for the surgical removal of tumors. Modular synthesis approaches allow the construction of hybrid probes consisting of a radiotracer, a fluorophore and a targeting unit. We present the synthesis of a new asymmetric bifunctional cyanine dye that can be used as a structural and functional linker for the construction of such hybrid probes.

Indexed as

AnimalsCarbocyaninesCell Line, TumorFluorescent DyesHumansMiceMice, NudeNeuroendocrine TumorsOctreotideOrganometallic CompoundsPeptidesPositron-Emission TomographyRadiopharmaceuticalsReceptors, SomatostatinSomatostatinTransplantation, HeterologousCarbocyaninesFluorescent DyesGa(III)-DOTATOCOctreotideOrganometallic CompoundsPeptidesRadiopharmaceuticalsReceptors, SomatostatinSomatostatinSSTR2 protein, humancyaninesfluorescencemultimodal imagingoctreotateSSTR2

Identifiers

PMID33238069
PMCPMC8048842
OpenAlexW3107433692

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.