Evidence map›Paper›PMID 33237662›Full record

ArticleTurkish journal of medical sciences2021

Investigation of the expression levels of CPEB4, APC, TRIP13, EIF2S3, EIF4A1, IFNg, PIK3CA and CTNNB1 genes in different stage colorectal tumors

Zafer Söylemez, Evrim Suna Arıkan, Mustafa Solak, Yüksel Arıkan, Çiğdem Tokyol, Hüseyin Şeker

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In one paragraph

Article in Turkish journal of medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Zafer SöylemezDepartment of Medical Biology, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, TurkeyORCID 0000-0002-0415-8118
Evrim Suna ArıkanDepartment of Medical Biology, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, TurkeyORCID 0000-0002-8550-793X
Mustafa SolakDepartment of Medical Genetic, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, TurkeyORCID 0000-0001-5348-9645
Yüksel ArıkanGeneral Surgery Department, Park Hayat Hospital, Afyonkarahisar, TurkeyORCID 0000-0002-6452-3666
Çiğdem TokyolDepartment of Patology, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, TurkeyORCID 0000-0001-5971-5295
Hüseyin ŞekerSchool of Computing and Digital Technologies, Staffordshire University, Stroke-on-Trent, United KingdomORCID 0000-0002-1255-9552
Afyonkarahisar Sağlık Bilimleri ÜniversitesiUniversity of Staffordshire · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/aim: The aim of the study is to assess expression levels of CPEB4, APC, TRIP13, EIF2S3, EIF4A1, IFNg, PIK3CA and CTNNB1 genes in tumors and peripheral bloods of colorectal cancer patients in stages I–IV. Materials and methods: The mRNA levels of the genes were determined in tumor tissues and peripheral blood samples of 45 colorectal cancer patients and colon tissues and peripheral blood samples of 5 healthy individuals. Real-time polymerase chain reaction method was used for the analysis. Results: The mRNA level of the CPEB4 gene was significantly downregulated in colorectal tumor tissues and was upregulated in the peripheral blood of colorectal cancer patients relative to the controls (P < 0.05). APC mRNA level was significantly downregulated in tissues and upregulated in the peripheral blood (P < 0.05). TRIP13 mRNA level was upregulated in peripheral blood and also significantly upregulated in colorectal tumor tissues (P < 0.05). EIF2S3 mRNA level was upregulated in tissues and also significantly upregulated in peripheral blood (P < 0.05). PIK3CA mRNA level was downregulated in tissues and upregulated in peripheral blood. EIF4A1 mRNA level was downregulated in tissues and significantly upregulated in peripheral blood (P < 0.05). CTNNB1 mRNA level was downregulated in tissues and upregulated in peripheral blood. IFNg mRNA level was upregulated in both colorectal cancer tumor tissues and peripheral blood. Conclusion: TRIP13 and CPEB4 mRNA up regulation in the peripheral blood of patients with colorectal cancer may be a potential target for early stage diagnosis. In addition to this evaluation, although there is not much study on EIF2S3 and EIF4A1 mRNA changes in cases with colorectal cancer, upregulation in peripheral blood draws attention in our study. These data will shed light on the new comprehensive studies.

Indexed as

ATPases Associated with Diverse Cellular Activitiesbeta CateninBiomarkersBiomarkers, TumorCell Cycle ProteinsClass I Phosphatidylinositol 3-KinasesColorectal NeoplasmsDown-RegulationGene ExpressionHumansInterferon-gammaReal-Time Polymerase Chain ReactionRNA-Binding ProteinsRNA, MessengerUp-RegulationATPases Associated with Diverse Cellular Activitiesbeta CateninBiomarkersBiomarkers, TumorCell Cycle ProteinsClass I Phosphatidylinositol 3-KinasesCPEB4 protein, humanCTNNB1 protein, humanIFNG protein, humanInterferon-gammaPIK3CA protein, humanRNA-Binding ProteinsRNA, MessengerTRIP13 protein, humanBiomarkercolorectal tumordifferent stagegene expression

Identifiers

PMID33237662
PMCPMC8208508
OpenAlexW3109465459

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.