Evidence map›Paper›PMID 33237594›Full record

ArticleMedical physics2021

Feature-based automated segmentation of ablation zones by fuzzy c-mean clustering during low-dose computed tomography.

Po-Hung Wu, Mariajose Bedoya, Jim White, Christopher L Brace

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Article in Medical physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

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7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

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3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Po-Hung WuDepartment of Electrical and Computer Engineering, University of Wisconsin - Madison, 1415 Engineering Drive, Madison, WI, 53706, USA.
Mariajose BedoyaDepartment of Medical Physics, University of Wisconsin - Madison, 1111 Highland Ave, Rm 1005, Madison, WI, 53705, USA.
Jim WhiteDepartment of Biomedical Engineering, University of Wisconsin - Madison, 1415 Engineering Drive, Madison, WI, 53706, USA.
Christopher L BraceDepartment of Biomedical Engineering, University of Wisconsin - Madison, 1415 Engineering Drive, Madison, WI, 53706, USA.

Funding

Periodic Contrast-Enhanced CT With HYPR Reconstruction For Ablation MonitoringR01CA149379 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI BRACE, CHRISTOPHER L · 2010 to 2014
$1.2M
National Institutes of Health (NIH) R01CA149379NCI NIH HHS R01 CA149379
6 · The paper itself

Abstract

purposeIntra-procedural monitoring and post-procedural follow-up is necessary for a successful ablation treatment. An imaging technique which can assess the ablation geometry accurately is beneficial to monitor and evaluate treatment. In this study, we developed an automated ablation segmentation technique for serial low-dose, noisy ablation computed tomography (CT) or contrast-enhanced CT (CECT).

methodsLow-dose, noisy temporal CT and CECT volumes were acquired during microwave ablation on normal porcine liver (four with non-contrast CT and eight with CECT). Highly constrained backprojection (HYPR) processing was used to recover ablation zone information compromised by low-dose noise. First-order statistic features and normalized fractional Brownian features (NBF) were used to segment ablation zones by fuzzy c-mean clustering. After clustering, the segmented ablation zone was refined by cyclic morphological processing. Automatic and manual segmentations were compared to gross pathology with Dice's coefficient (morphological similarity), while cross-sectional dimensions were compared by percent difference.

resultsAutomatic and manual segmentations of the ablation zone were very similar to gross pathology (Dice Coefficients: Auto.-Path. = 0.84 ± 0.02; Manu.-Path. = 0.76 ± 0.03, P = 0.11). The differences in ablation area, major diameter and minor diameter were 17.9 ± 3.2%, 11.1 ± 3.2% and 16.2 ± 3.4%, respectively, when comparing automatic segmentation to gross pathology, which were lower than the differences of 32.9 ± 16.8%, 13.0 ± 9.8% and 21.8 ± 5.8% when comparing manual segmentation to gross pathology. Manual segmentations tended to overestimate gross pathology when ablation area was less than 15 cm

conclusionFuzzy c-means clustering may be used to aid automatic segmentation of ablation zones without prior information or user input, making serial CT/CECT has more potential to assess treatments intra-procedurally.

Indexed as

Ablation TechniquesRadiofrequency AblationAnimalsCluster AnalysisCross-Sectional StudiesSwineTomography, X-Ray Computedcomputed tomography (CT)feature extractionimage segmentationMicrowave ablation monitoring

Identifiers

PMID33237594
PMCPMC8594246

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