Evidence map›Paper›PMID 33237586›Full record

ArticleEMBO reports2020

Hepatocyte ploidy modulation in liver cancer.

Andrew W Duncan

Open access · hybridAbstract readNewsComment
In one paragraph

Article in EMBO reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Evolutionary View of Liver Pathology.Evolutionary applications · 2024
    Review
  2. Role of miRNA‑122 in cancer (Review).International journal of oncology · 2024
    Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Andrew W DuncanDepartment of Pathology, McGowan Institute for Regenerative Medicine, Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA.
McGowan Institute for Regenerative Medicine · US

Funding

Mechanisms of Polyploidy and Aneuploidy in the LiverR01DK103645 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DUNCAN, ANDREW W · 2014 to 2023
$4.1M
NIDDK NIH HHS R01 DK103645
6 · The paper itself

Abstract

Polyploidy, a balanced amplification of the genome, is common in the liver. The function of hepatic polyploidy is not entirely clear, but growing evidence shows that polyploidy can protect the liver from tumor formation. In this issue of EMBO Reports, Sladky and colleagues identify the PIDDosome as a polyploidy sensor that regulates liver cancer (Sladky et al, 2020b).

Indexed as

Liver NeoplasmsTumor Suppressor Protein p53HepatocytesHumansLiverPloidiesPolyploidyTumor Suppressor Protein p53

Identifiers

PMID33237586
PMCPMC7726811
OpenAlexW3109260033

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.