Evidence map›Paper›PMID 33237528›Full record

ArticleBulletin of experimental biology and medicine2020

Thymalin: Activation of Differentiation of Human Hematopoietic Stem Cells.

V Kh Khavinson, N S Linkova, I M Kvetnoy, V O Polyakova, A O Drobintseva, T V Kvetnaia, O M Ivko

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

V Kh KhavinsonDepartment of Biogerontology, St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
N S LinkovaDepartment of Biogerontology, St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia. linkova8101984@gmail.com.
I M KvetnoyDepartment of Biogerontology, St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
V O PolyakovaDepartment of Biogerontology, St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
A O DrobintsevaDepartment of Biogerontology, St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
T V KvetnaiaDepartment of Biogerontology, St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
O M IvkoDepartment of Biogerontology, St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
St. Petersburg Institute of Bioregulation and Gerontology · RUPavlov Institute of Physiology of the Russian Academy of Sciences · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thymalin is a polypeptide complex isolated from the thymus and regulating the functions of the immune system. Thymalin is effective in therapy of acute respiratory syndrome, chronic obstructive bronchitis, and other immunopathology. Thymalin increases functional activity of T lymphocytes, but the targeted molecular mechanism of its biological activity requires further study. We studied the influence of thymalin on differentiation of human hematopoietic stem cells (HSC) and expression of CD28 molecule involved in the implementation of antiviral immunity in COVID-19 infection. It was found that thymalin reduced the expression of CD44 (stem cell marker) and CD117 (molecule of the intermediate stage of HSC differentiation) by 2-3 times and increased the expression of CD28 (marker of mature T lymphocytes) by 6.8 times. This indirectly indicates that thymalin stimulated differentiation of CD117

Indexed as

CD28 AntigensCell DifferentiationCells, CulturedCOVID-19Fetal BloodGene Expression RegulationHematopoietic Stem CellsHumansHyaluronan ReceptorsProto-Oncogene Proteins c-kitSARS-CoV-2Thymus HormonesT-LymphocytesCD28 AntigensCD44 protein, humanHyaluronan ReceptorsKIT protein, humanProto-Oncogene Proteins c-kitthymalinThymus Hormonescell differentiationCOVID-19hematopoietic stem cellspeptidesthymalin

Identifiers

PMID33237528
PMCPMC7686446
OpenAlexW3107737101

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.