Evidence map›Paper›PMID 33237520›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2021

Quinoline Derivative Enhances Human Sperm Motility and Improves the Functional Competence.

Sandhya Kumari, Sujith Raj Salian, Arpitha Rao, Shilpa M Somagond, Ravindra R Kamble, Aravind Nesaragi, Jyotirekha Das, G K Rajanikant, Srinivas Mutalik, Shamprasad Varija Raghu and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Sandhya KumariDepartment of Clinical Embryology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576 104, India.
Sujith Raj SalianDepartment of Clinical Embryology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576 104, India.
Arpitha RaoDepartment of Clinical Embryology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576 104, India.
Shilpa M SomagondDepartment of Studies in Chemistry, Karnatak University, Dharwad, Karnataka, 580 003, India.
Ravindra R KambleDepartment of Studies in Chemistry, Karnatak University, Dharwad, Karnataka, 580 003, India.
Aravind NesaragiDepartment of Studies in Chemistry, Karnatak University, Dharwad, Karnataka, 580 003, India.
Jyotirekha DasSchool of Biotechnology, National Institute of Technology Calicut, Calicut, Kerala, 673 601, India.
G K RajanikantSchool of Biotechnology, National Institute of Technology Calicut, Calicut, Kerala, 673 601, India.
Srinivas MutalikDepartment of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576 104, India.
Shamprasad Varija RaghuNeurogenetics Lab, Department of Applied Zoology, Mangalore University, Mangalaganothri, Konaje, Karnataka, 574199, India.
Satish Kumar AdigaDepartment of Clinical Embryology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576 104, India.
Guruprasad KalthurDepartment of Clinical Embryology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576 104, India. guru.kalthur@manipal.edu.ORCID http://orcid.org/0000-0002-4554-2917
Manipal Academy of Higher Education · INKarnatak University · INNational Institute of Technology Calicut · INMangalore University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we aimed to explore the beneficial properties of novel quinoline derivatives on human sperm motility and its functional competence. Nine novel quinoline derivatives were screened for their effect on motility in human spermatozoa from normozoospermic ejaculates. Compounds with impressive sperm motility enhancement properties were further assessed for their effect on functional competence of human spermatozoa. To determine the effect on the fertilizing ability of spermatozoa processed with quinoline derivatives and to assess developmental competence of embryos derived, in vitro fertilization (IVF) was performed using mouse model. Among the nine quinoline derivatives, 2 compounds (6MQT and 2,6DQT) exhibited significant enhancement in sperm progressive motility and survival at 24 h. Further, non-significant increase in curvilinear velocity (VCL), straight line velocity (VSL), and amplitude of lateral head displacement (ALH) was observed. Capacitation, intracellular cAMP level and tyrosine phosphorylated sperm proteins were significantly higher in 6MQT (P < 0.05) and 2,6DQT (P < 0.001) compared to control. In vitro fertilization (IVF) experiments using Swiss albino mice revealed that spermatozoa processed with 6MQT had non-significantly higher blastocyst rate and a superior blastocyst quality, while, 2,6DQT resulted in significantly lower blastocyst rate (P < 0.05) compared to control. Quinoline derivative 6MQT has significant motility enhancement property under in vitro conditions. Graphical abstract.

Indexed as

AnimalsHumansMaleMembrane Potential, MitochondrialMiceQuinolinesSpermatozoaSperm MotilityquinolineQuinolinesCyclic AMPFertilizationPhosphodiesterase inhibitorsQuinoline derivativeSperm motilityTyrosine phosphorylation of sperm protein

Identifiers

PMID33237520
PMCPMC8076127
OpenAlexW3110173917

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.