Evidence map›Paper›PMID 33237467›Full record

ArticleSurgical endoscopy2021

Risk factors for delayed bleeding after endoscopic submucosal dissection of colorectal tumors.

Ran Li, Shilun Cai, Di Sun, Qiang Shi, Zhong Ren, Zhipeng Qi, Bing Li, Liqing Yao, Meidong Xu, Pinghong Zhou and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Surgical endoscopy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
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  20. Colorectal Endoscopic Submucosal Dissection: An Update on Best Practice.Clinical and experimental gastroenterology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Ran Li *Endoscopy Center, Zhongshan Hospital Fudan University, Shanghai, 200032, China.
Shilun Cai *Endoscopy Center, Zhongshan Hospital Fudan University, Shanghai, 200032, China.
Di Sun *Endoscopy Center, Zhongshan Hospital Fudan University, Shanghai, 200032, China.
Qiang ShiEndoscopy Center, Zhongshan Hospital Fudan University, Shanghai, 200032, China.
Zhong RenEndoscopy Center, Zhongshan Hospital Fudan University, Shanghai, 200032, China.
Zhipeng QiEndoscopy Center, Zhongshan Hospital Fudan University, Shanghai, 200032, China.
Bing LiEndoscopy Center, Zhongshan Hospital Fudan University, Shanghai, 200032, China.
Liqing YaoEndoscopy Center, Zhongshan Hospital Fudan University, Shanghai, 200032, China.
Meidong XuEndoscopy Center, Zhongshan Hospital Fudan University, Shanghai, 200032, China.
Pinghong ZhouEndoscopy Center, Zhongshan Hospital Fudan University, Shanghai, 200032, China.
Yunshi ZhongEndoscopy Center, Zhongshan Hospital Fudan University, Shanghai, 200032, China. zhongyunshi@Yahoo.com.ORCID 0000-0002-3128-3168
Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the risk factors for delayed bleeding following endoscopic submucosal dissection (ESD) for colorectal neoplasms.

methodsWe retrospectively reviewed the medical records of 991 consecutive patients who underwent ESD for colorectal neoplasms at our hospital from January 2007 to November 2016. Delayed post-ESD bleeding was defined as bleeding within 6 h to 30 days after ESD that resulted in either of the three situations: overt hematochezia, bleeding spots confirmed by repeat colonoscopy, or the requirement of a blood transfusion. Delayed bleeding was furtherly separated into early and late delayed bleeding by the end of post-ESD day 2. We analyzed the relationship between delayed bleeding and candidate factors including patient-, lesion-, and treatment-related details.

resultsDelayed post-ESD bleeding was found in 47 patients (4.7%), of which 18 cases were late delayed bleeding. Among all patients, 14 patients required a second colonoscopy, and 2 other patients were transferred to surgery. Univariate analysis revealed that patients with hypertension (p = 0.017) and using hot biopsy forceps for wound management (p = 0.028) were significantly associated with late delayed bleeding. Both risk factors remained significant after multivariate analysis: hypertension (OR 2.829, 95% CI 1.101-7.265, p = 0.031), hot biopsy forceps (OR 2.873, 95% CI 1.013-8.147, p = 0.047). Using hot biopsy forceps was also the significant risk factor for late delayed bleeding compared with early delayed bleeding.

conclusionPatient with hypertension and using hot biopsy forceps for wound management during procedure call for attention on high risk of delayed post-ESD bleeding. Therefore, additional perioperative treatment is recommended in patients with these risk factors.

Indexed as

Colorectal NeoplasmsEndoscopic Mucosal ResectionColonoscopyHumansPostoperative HemorrhageRetrospective StudiesRisk FactorsTime FactorsColorectal neoplasmsDelayed bleedingEndoscopic submucosal dissectionRisk factors

Identifiers

PMID33237467
OpenAlexW3109342415

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.