Evidence map›Paper›PMID 33237431›Full record

Observational studyNeuroradiology2021

Longitudinal study in patients with myotonic dystrophy type 1: correlation of brain MRI abnormalities with cognitive performances.

T Cabada, J Díaz, M Iridoy, P López, I Jericó, P Lecumberri, B Remirez, R Seijas, M Gomez

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

T CabadaRadiology Department, Complejo Hospitalario De Navarra, IdiSNa (Instituto de Investigación Sanitaria de Navarra), C/ Irunlarrea 3, 31008, Pamplona, Navarra, Spain. tcabadag@cfnavarra.es.ORCID http://orcid.org/0000-0001-9219-0064
J DíazMental Health Department, Complejo Hospitalario De Navarra, Pamplona, Spain.
M IridoyNeurology Department, Hospital De Zumarraga, Zumárraga, Spain.
P LópezRadiology Department, Complejo Hospitalario De Navarra, Pamplona, Spain.
I JericóNeurology Department, Complejo Hospitalario de Navarra, IdiSNa (Instituto de Investigación Sanitaria de Navarra), Pamplona, Spain.
P LecumberriMathematics Department, Universidad Publica De Navarra, Pamplona, Spain.
B RemirezMathematics Department, Universidad Publica De Navarra, Pamplona, Spain.
R SeijasNeurology Department, Complejo Hospitalario De Navarra, Pamplona, Spain.
M GomezMathematics Department, Universidad Publica De Navarra, IdiSNa (Instituto de Investigación Sanitaria de Navarra), Pamplona, Spain.

Funding

SERAM 01_TCG_INVESTIGACIÓN_SERAM.INDUSTRIA_18.
6 · The paper itself

Abstract

purposeMyotonic dystrophy type 1 (DM1) is a muscular dystrophy with neurological, cognitive, and radiological abnormalities. The developmental or degenerative nature of these abnormalities, and their progression over time, remains unclear. The aim of this study is to perform a longitudinal assessment of imaging and cognitive performances in a group of patients with DM1.

methodsA longitudinal observational study was conducted in a group of 33 DM1 patients. All patients underwent cognitive and MRI evaluation, including the use of structural and diffusion tensor imaging techniques, at baseline and follow-up evaluation (4 years). Longitudinal changes in white matter lesion (WML), volumetric analysis, and diffusivity values were assessed and correlated with neuropsychological test findings.

resultsAn increase in WML was observed in 16 patients (48.5%). An increase in ventricular system volume and a decrease in volume of the left thalamus, caudates, putamen, and hippocampus were observed (p < 0.001). Global cortical volume showed a significant decrease (p < 0.001), although no changes were observed in white matter volume. A significant increase in mean diffusivity and decrease in fractional anisotropy for the white matter were found (p < 0.001). Neuropsychological evaluation showed a significant deterioration in test performance that measures working memory (Letter-Number Sequencing, p = 0.049) and visuospatial skills (Benton Visual Retention Test, p = 0.001). These findings were significantly associated with WML load (working memory p = 0.002 and visuospatial skills p = 0.021) and mean diffusivity increase (visuospatial skills p = 0.003 in the corpus callosum and working memory p = 0.043 in the right cerebral white matter).

conclusionWhite matter and grey matter involvement in DM1 patients is progressive. Patients experience a worsening in cognitive impairment that correlates with white matter involvement. These findings support the neurodegenerative nature of this disease.

Indexed as

Myotonic DystrophyWhite MatterBrainCognitionDiffusion Tensor ImagingHumansLongitudinal StudiesMagnetic Resonance ImagingNeuropsychological TestsDiffusion tensor imagingMagnetic resonance imagingMyotonic dystrophyWhite matter

Identifiers

PMID33237431

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.