Evidence map›Paper›PMID 33237428›Full record

ArticleBasic research in cardiology2020

Hyperglycemia regulates cardiac K

Bence Hegyi, Johanna M Borst, Logan R J Bailey, Erin Y Shen, Austen J Lucena, Manuel F Navedo, Julie Bossuyt, Donald M Bers

Open access · greenAbstract read
In one paragraph

Article in Basic research in cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
6.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 72 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Bence HegyiDepartment of Pharmacology, University of California Davis, 451 Health Sciences Drive, Davis, CA, USA.
Johanna M BorstDepartment of Pharmacology, University of California Davis, 451 Health Sciences Drive, Davis, CA, USA.
Logan R J BaileyDepartment of Pharmacology, University of California Davis, 451 Health Sciences Drive, Davis, CA, USA.
Erin Y ShenDepartment of Pharmacology, University of California Davis, 451 Health Sciences Drive, Davis, CA, USA.
Austen J LucenaDepartment of Pharmacology, University of California Davis, 451 Health Sciences Drive, Davis, CA, USA.
Manuel F NavedoDepartment of Pharmacology, University of California Davis, 451 Health Sciences Drive, Davis, CA, USA.
Julie BossuytDepartment of Pharmacology, University of California Davis, 451 Health Sciences Drive, Davis, CA, USA.
Donald M BersDepartment of Pharmacology, University of California Davis, 451 Health Sciences Drive, Davis, CA, USA. dmbers@ucdavis.edu.ORCID 0000-0002-2237-9483
University of California, Davis · US

Funding

Project 3 (Mercola)P01HL141084 · NHLBI · STANFORD UNIVERSITY · PI Joseph C. Wu · 2019 to 2026
$21.1M
Pathophysiological Regulation of Cardiac Myocyte RyR ChannelR01HL092097 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Donald M Bers, Robyn T Rebbeck · 2010 to 2026
$9.3M
CaMKII activation and regulation in adult cardiac myocytesR01HL142282 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M, BOSSUYT, JULIE B · 2018 to 2025
$5.4M
IONIC CONTROL OF CARDIAC MUSCLE CONTRACTION: EC COUPLINGR01HL030077 · NHLBI · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI BERS, DONALD M · 1986 to 2018
$3.8M
Calcium Sparklets-Induced Vascular Dysfunction During DiabetesR01HL098200 · NHLBI · UNIVERSITY OF WASHINGTON · PI NAVEDO, MANUEL F · 2010 to 2019
$3.5M
NHLBI NIH HHS P01 HL141084NHLBI NIH HHS R01 HL030077NHLBI NIH HHS R01 HL092097NHLBI NIH HHS R01 HL098200NHLBI NIH HHS R01 HL142282
6 · The paper itself

Abstract

Chronic hyperglycemia and diabetes lead to impaired cardiac repolarization, K

Indexed as

AnimalsArrhythmias, CardiacBlood GlucoseCalcium-Calmodulin-Dependent Protein Kinase Type 2Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2GlycosylationMaleMice, Inbred C57BLMice, TransgenicMyocytes, CardiacNADPH Oxidase 2Potassium ChannelsProtein Kinase CRabbitsReactive Oxygen SpeciesBlood GlucoseCalcium-Calmodulin-Dependent Protein Kinase Type 2Camk2d protein, mouseCamk2d protein, ratCybb protein, mouseCybb protein, ratNADPH Oxidase 2Potassium ChannelsProtein Kinase CReactive Oxygen SpeciesCaMKIIDiabetesHyperglycemiaPotassium channelsROS

Identifiers

PMID33237428
PMCPMC8349245
OpenAlexW3107476898

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.