Evidence map›Paper›PMID 33237361›Full record

Trial reportEuropean archives of psychiatry and clinical neuroscience2021

Beyond physiotherapy and pharmacological treatment for fibromyalgia syndrome: tailored tACS as a new therapeutic tool.

Laura Bernardi, Margherita Bertuccelli, Emanuela Formaggio, Maria Rubega, Gerardo Bosco, Elena Tenconi, Manuela Cattelan, Stefano Masiero, Alessandra Del Felice

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European archives of psychiatry and clinical neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03221413 (A Translational, Multimodal Approach to Implementing Non-invasive Paradigms for the Treatment of Oscillopathies), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03221413 nacompletednot on this map

A Translational, Multimodal Approach to Implementing Non-invasive Paradigms for the Treatment of Oscillopathies

TypeinterventionalSponsorUniversity of PadovaRan2016 to 2019Enrolled30ConditionsParkinson Disease, PainArmstranscranial alternating current stimulation (tACS)
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Reaction Time in Fibromyalgia Patients.Current rheumatology reviews · 2024
    Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Transcranial alternating current stimulation (tACS) as a treatment for fibromyalgia syndrome?European archives of psychiatry and clinical neuroscience · 2022
    Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Laura Bernardi *Department of Neuroscience, Section of Rehabilitation, University of Padova, via Giustiniani 3, 35128, Paduas, Italy.
Margherita Bertuccelli *Department of Neuroscience, Section of Rehabilitation, University of Padova, via Giustiniani 3, 35128, Paduas, Italy. margherita.bertuccelli@phd.unipd.it.ORCID http://orcid.org/0000-0002-8907-4051
Emanuela FormaggioDepartment of Neuroscience, Section of Rehabilitation, University of Padova, via Giustiniani 3, 35128, Paduas, Italy.
Maria RubegaDepartment of Neuroscience, Section of Rehabilitation, University of Padova, via Giustiniani 3, 35128, Paduas, Italy.
Gerardo BoscoDepartment of Biomedical Sciences, University of Padova, Via Marzolo 3, 35031, Padua, Italy.
Elena TenconiDepartment of Neuroscience and Padova Neuroscience Center, Psychiatric Clinic, University of Padova, Via Giustiniani 3, 35128, Padua, Italy.
Manuela CattelanDepartment of Statistical Sciences, University of Padova, via C. Battisti 241, 35121, Padua, Italy.
Stefano MasieroDepartment of Neuroscience, Section of Rehabilitation, University of Padova, via Giustiniani 3, 35128, Paduas, Italy.
Alessandra Del FeliceDepartment of Neuroscience, Section of Rehabilitation, University of Padova, via Giustiniani 3, 35128, Paduas, Italy.
University of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibromyalgia syndrome (FMS) is a complex pain disorder, characterized by diffuse pain and cognitive disturbances. Abnormal cortical oscillatory activity may be a promising biomarker, encouraging non-invasive neurostimulation techniques as a treatment. We aimed to modulate abnormal slow cortical oscillations by delivering transcranial alternating current stimulation (tACS) and physiotherapy to reduce pain and cognitive symptoms. This was a double-blinded, randomized, crossover trial conducted between February and September 2018 at the Rehabilitation Unit of a teaching Hospital (NCT03221413). Participants were randomly assigned to tACS or random noise stimulation (RNS), 5 days/week for 2 weeks followed by ad hoc physiotherapy. Clinical and cognitive assessments were performed at T

Indexed as

Physical Therapy ModalitiesTranscranial Direct Current StimulationCross-Over StudiesDouble-Blind MethodElectroencephalographyFemaleFibromyalgiaHumansMaleMiddle AgedPainFibrofogNon-invasive transcranial stimulationPainRandom noise stimulation (RNS)Rehabilitation

Identifiers

PMID33237361
PMCPMC7867558
OpenAlexW3109817582

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.