Evidence map›Paper›PMID 33237329›Full record

ArticleNucleic acids research2021

MobiDB: intrinsically disordered proteins in 2021.

Damiano Piovesan, Marco Necci, Nahuel Escobedo, Alexander Miguel Monzon, András Hatos, Ivan Mičetić, Federica Quaglia, Lisanna Paladin, Pathmanaban Ramasamy, Zsuzsanna Dosztányi and 5 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers.

0numbers the graph read from it
0cells of the map it votes in
141citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

141 citing papers in PubMed.

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  8. Review
  9. Article
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  14. IsoProDB: an integrated map of human protein isoforms for accelerated research.Database : the journal of biological databases and curation · 2026
    Article
  15. Expose flexible conformations for intrinsically disordered protein.Current research in structural biology · 2025
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

81 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Damiano PiovesanDept. of Biomedical Sciences, University of Padua, Via Ugo Bassi 58/B, Padua 35121, Italy.
Marco NecciDept. of Biomedical Sciences, University of Padua, Via Ugo Bassi 58/B, Padua 35121, Italy.
Nahuel EscobedoDept. of Science and Technology, Universidad Nacional de Quilmes, Buenos Aires, Argentina.
Alexander Miguel MonzonDept. of Biomedical Sciences, University of Padua, Via Ugo Bassi 58/B, Padua 35121, Italy.
András HatosDept. of Biomedical Sciences, University of Padua, Via Ugo Bassi 58/B, Padua 35121, Italy.
Ivan MičetićDept. of Biomedical Sciences, University of Padua, Via Ugo Bassi 58/B, Padua 35121, Italy.
Federica QuagliaDept. of Biomedical Sciences, University of Padua, Via Ugo Bassi 58/B, Padua 35121, Italy.
Lisanna PaladinDept. of Biomedical Sciences, University of Padua, Via Ugo Bassi 58/B, Padua 35121, Italy.
Pathmanaban RamasamyInteruniversity Institute of Bioinformatics in Brussels, ULB/VUB, Triomflaan, BC building, 6th floor, CP 263, 1050 Brussels, Belgium.
Zsuzsanna DosztányiDept. of Biochemistry, ELTE Eötvös Loránd University, Budapest, Hungary.
Wim F VrankenInteruniversity Institute of Bioinformatics in Brussels, ULB/VUB, Triomflaan, BC building, 6th floor, CP 263, 1050 Brussels, Belgium.
Norman E DaveyDivision of Cancer Biology, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK.
Gustavo ParisiDept. of Science and Technology, Universidad Nacional de Quilmes, Buenos Aires, Argentina.
Monika FuxreiterDept. of Biomedical Sciences, University of Padua, Via Ugo Bassi 58/B, Padua 35121, Italy.
Silvio C E TosattoDept. of Biomedical Sciences, University of Padua, Via Ugo Bassi 58/B, Padua 35121, Italy.

Funding

Cancer Research UK 28159Cancer Research UK C68484/A28159
6 · The paper itself

Abstract

The MobiDB database (URL: https://mobidb.org/) provides predictions and annotations for intrinsically disordered proteins. Here, we report recent developments implemented in MobiDB version 4, regarding the database format, with novel types of annotations and an improved update process. The new website includes a re-designed user interface, a more effective search engine and advanced API for programmatic access. The new database schema gives more flexibility for the users, as well as simplifying the maintenance and updates. In addition, the new entry page provides more visualisation tools including customizable feature viewer and graphs of the residue contact maps. MobiDB v4 annotates the binding modes of disordered proteins, whether they undergo disorder-to-order transitions or remain disordered in the bound state. In addition, disordered regions undergoing liquid-liquid phase separation or post-translational modifications are defined. The integrated information is presented in a simplified interface, which enables faster searches and allows large customized datasets to be downloaded in TSV, Fasta or JSON formats. An alternative advanced interface allows users to drill deeper into features of interest. A new statistics page provides information at database and proteome levels. The new MobiDB version presents state-of-the-art knowledge on disordered proteins and improves data accessibility for both computational and experimental users.

Indexed as

Databases, ProteinAlgorithmsInternetIntrinsically Disordered ProteinsMolecular Sequence AnnotationProtein Processing, Post-TranslationalSoftwareIntrinsically Disordered Proteins

Identifiers

PMID33237329
PMCPMC7779018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.