Evidence map›Paper›PMID 33237313›Full record

ArticleNucleic acids research2021

RepeatsDB in 2021: improved data and extended classification for protein tandem repeat structures.

Lisanna Paladin, Martina Bevilacqua, Sara Errigo, Damiano Piovesan, Ivan Mičetić, Marco Necci, Alexander Miguel Monzon, Maria Laura Fabre, Jose Luis Lopez, Juliet F Nilsson and 13 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Diversity and structural-functional insights of alpha-solenoid proteins.Protein science : a publication of the Protein Society · 2024
    Review
  11. Structured Tandem Repeats in Protein Interactions.International journal of molecular sciences · 2024
    Article
  12. Article
  13. Review
  14. Article
  15. Design, synthesis, and characterization of protein origami based on self-assembly of a brick and staple artificial protein pair.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  16. Article
  17. Evolution and folding of repeat proteins.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  18. Review
  19. DbStRiPs: Database of structural repeats in proteins.Protein science : a publication of the Protein Society · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Lisanna PaladinDept. of Biomedical Sciences, University of Padua, Via Ugo Bassi 58/B, Padua 35121, Italy.
Martina BevilacquaDept. of Biomedical Sciences, University of Padua, Via Ugo Bassi 58/B, Padua 35121, Italy.
Sara ErrigoDept. of Biomedical Sciences, University of Padua, Via Ugo Bassi 58/B, Padua 35121, Italy.
Damiano PiovesanDept. of Biomedical Sciences, University of Padua, Via Ugo Bassi 58/B, Padua 35121, Italy.
Ivan MičetićDept. of Biomedical Sciences, University of Padua, Via Ugo Bassi 58/B, Padua 35121, Italy.
Marco NecciDept. of Biomedical Sciences, University of Padua, Via Ugo Bassi 58/B, Padua 35121, Italy.
Alexander Miguel MonzonDept. of Biomedical Sciences, University of Padua, Via Ugo Bassi 58/B, Padua 35121, Italy.
Maria Laura FabreIBBM-CONICET, Dept. of Biological Sciences, La Plata National University, 49 y 115, 1900 La Plata, Argentina.
Jose Luis LopezIBBM-CONICET, Dept. of Biological Sciences, La Plata National University, 49 y 115, 1900 La Plata, Argentina.
Juliet F NilssonIBBM-CONICET, Dept. of Biological Sciences, La Plata National University, 49 y 115, 1900 La Plata, Argentina.
Javier RiosDept. of Science and Technology, National University of Quilmes, Roque Sáenz Peña 352, Bernal, Buenos Aires, Argentina.
Pablo Lorenzano MennaDept. of Science and Technology, National University of Quilmes, Roque Sáenz Peña 352, Bernal, Buenos Aires, Argentina.
Maia CabreraDept. of Science and Technology, National University of Quilmes, Roque Sáenz Peña 352, Bernal, Buenos Aires, Argentina.
Martin Gonzalez BuitronDept. of Science and Technology, National University of Quilmes, Roque Sáenz Peña 352, Bernal, Buenos Aires, Argentina.
Mariane Gonçalves KulikInstitute of Organismic and Molecular Evolution, Faculty of Biology, Johannes Gutenberg University of Mainz, Hans-Dieter-Hüsch-Weg 15, 55128 Mainz, Germany.
Sebastian Fernandez-AlbertiDept. of Science and Technology, National University of Quilmes, Roque Sáenz Peña 352, Bernal, Buenos Aires, Argentina.
Maria Silvina FornasariDept. of Science and Technology, National University of Quilmes, Roque Sáenz Peña 352, Bernal, Buenos Aires, Argentina.
Gustavo ParisiDept. of Science and Technology, National University of Quilmes, Roque Sáenz Peña 352, Bernal, Buenos Aires, Argentina.
Antonio LagaresIBBM-CONICET, Dept. of Biological Sciences, La Plata National University, 49 y 115, 1900 La Plata, Argentina.
Layla HirshDept. of Engineering, Faculty of Science and Engineering, Pontifical Catholic University of Peru, Av. Universitaria 1801 San Miguel, Lima 32, Lima, Peru.
Miguel A Andrade-NavarroInstitute of Organismic and Molecular Evolution, Faculty of Biology, Johannes Gutenberg University of Mainz, Hans-Dieter-Hüsch-Weg 15, 55128 Mainz, Germany.
Andrey V KajavaCentre de Recherche en Biologie cellulaire de Montpellier, UMR 5237, CNRS, Univ. Montpellier, Montpellier, France.
Silvio C E TosattoDept. of Biomedical Sciences, University of Padua, Via Ugo Bassi 58/B, Padua 35121, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The RepeatsDB database (URL: https://repeatsdb.org/) provides annotations and classification for protein tandem repeat structures from the Protein Data Bank (PDB). Protein tandem repeats are ubiquitous in all branches of the tree of life. The accumulation of solved repeat structures provides new possibilities for classification and detection, but also increasing the need for annotation. Here we present RepeatsDB 3.0, which addresses these challenges and presents an extended classification scheme. The major conceptual change compared to the previous version is the hierarchical classification combining top levels based solely on structural similarity (Class > Topology > Fold) with two new levels (Clan > Family) requiring sequence similarity and describing repeat motifs in collaboration with Pfam. Data growth has been addressed with improved mechanisms for browsing the classification hierarchy. A new UniProt-centric view unifies the increasingly frequent annotation of structures from identical or similar sequences. This update of RepeatsDB aligns with our commitment to develop a resource that extracts, organizes and distributes specialized information on tandem repeat protein structures.

Indexed as

Databases, ProteinRepetitive Sequences, Amino AcidTandem Repeat SequencesGene OntologyHEK293 CellsHeLa CellsHumansProteinsReproducibility of ResultsStatistics as TopicUser-Computer InterfaceProteins

Identifiers

PMID33237313
PMCPMC7778985

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.