ArticleActa cirurgica brasileira2020
Periplaneta americana extract promotes intestinal mucosa repair of ulcerative colitis in rat.
Article in Acta cirurgica brasileira, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
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- Animal models of inflammatory bowel disease: category and evaluation indexes.Gastroenterology report · 2024Review
- Research advances on the restorative effect ofHeliyon · 2023Review
- Periplaneta Americana extract inhibits osteoclastic differentiation in vitro.Cell proliferation · 2023Article
- Efficiency of a novel thermosensitive enemaFrontiers in pharmacology · 2023Article
- Development of microparticles for oral administration ofDrug delivery · 2022Article
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- The Regulating Effect of CII-3 and Its Active Components fromMolecules (Basel, Switzerland) · 2022Article
- Treatment of colitis by oral negatively charged nanostructured curcumin in rats.Acta cirurgica brasileira · 2022Article
- Rectal administration of Panax notoginseng and Colla Corii Asini suppositories in ulcerative colitis: clinical effect and influence on immune function.American journal of translational research · 2022Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the mechanism of Periplaneta americana extract promoting intestinal mucosal repair of OXZ-induced colitis in rat.
methodsAll experiments used an equal number of male and female SD rats (n=48). We injected OXZ into the colon to induce UC rat model. To determine the optimal concentration of P. Americana's extract (PA-40), it was classified into low (L), medium (M), and high (H) doses. After OXZ treatment, each drug was administered by enema for 7 consecutive days. Rats were divided into the following 6 groups: (1) Saline treatment group (NC), (2) OXZ treatment UC model group (MC), (3) OXZ + budesonide group (BUN), (4) OXZ + PA-40 L group, (5) OXZ + PA-40 M group, (6) OXZ + PA-40 H group. Disease activity index (DAI) scores, colon length, histopathological score, serum cytokine level (IL-4, IL-10, iNOS, tNOS), and amount of MPO, EGF, IL-13 in colonic mucosa were measured.
resultsPA treatment had a significant healing effect on the OXZ-colitis model and significantly reduced the lesioned area, especially in the PA-40H groups. PA treatment did not alter the expression of IL-10 and MPO level, but increased EGF (epidermal growth factor) and decrease IL-13 in the colonic tissue. PA inhibited the rise of NOSs (nitric oxide synthase) and decreased the serum IL-4 level.
conclusionsThe data suggest that Periplaneta americana extract may be a potential compound for the treatment of colonic lesions. The mechanism may be related to inhibiting the secretion of IL-13 and promoting the formation of EGF.
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