ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2021
An electronic, unsupervised patient-reported Expanded Disability Status Scale for multiple sclerosis.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Clinician-led, single-blind, randomised controlled trial evaluating the efficacy of a high-intensity resistance and impact training intervention for improving health-related quality of life in people with multiple sclerosis: protocol for STRONG-MS.BMJ open sport & exercise medicine · 2026Article
- The epidemiology, pathology and pathogenesis of MS: Therapeutic implications.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- From checkboxes to emojis: a novel approach to patient-reported outcomes in multiple sclerosis.Journal of neurology · 2025Article
- MyMS: An Interface for Patient-Reported Outcomes for Finnish Individuals With Multiple Sclerosis.International journal of MS care · 2024Article
- Article
- "Self-care selfies": Patient-uploaded videos capture meaningful changes in dexterity over 6 months.Annals of clinical and translational neurology · 2023Article
- Remote Observational Research for Multiple Sclerosis: A Natural Experiment.Neurology(R) neuroimmunology & neuroinflammation · 2023Article
- Symptom-Level Disability Status Assessed with an Electronic Unsupervised Patient-Reported Expanded Disability Status Scale (ePR-EDSS) in Multiple Sclerosis Patients-The Example of Croatia.Journal of clinical medicine · 2022Article
- Effects of melatonin on sleep disturbances in multiple sclerosis: A randomized, controlled pilot study.Multiple sclerosis journal - experimental, translational and clinical · 2021Article
- Clinical and Research Applications of the Electronic Medical Record in Multiple Sclerosis: A Narrative Review of Current Uses and Future Applications.International journal of MS careArticle
- Closing the referral gap: The role of a quality improvement initiative to enhance pelvic health physical therapy referrals for persons with multiple sclerosis-related bladder symptoms.Multiple sclerosis journal - experimental, translational and clinicalArticle
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
backgroundIn persons with multiple sclerosis (MS), the Expanded Disability Status Scale (EDSS) is the criterion standard for assessing disability, but its in-person nature constrains patient participation in research and clinical assessments.
objectiveThe aim of this study was to develop and validate a scalable, electronic, unsupervised patient-reported EDSS (ePR-EDSS) that would capture MS-related disability across the spectrum of severity.
methodsWe enrolled 136 adult MS patients, split into a preliminary testing Cohort 1 (
resultsIn Cohort 2, mean age was 50.6 years (range = 26-80) and median EDSS was 3.5 (interquartile range (IQR) = [1.5, 5.5]). The ePR-EDSS and EDSS agreed within 1-point for 86% of examinations; kappa for agreement within 1-point was 0.85 ( DISCUSSION: The ePR-EDSS was highly correlated with EDSS, with good agreement even at lower EDSS levels. For clinical care, the ePR-EDSS could enable the longitudinal monitoring of a patient's disability. For research, it provides a valid and rapid measure across the entire spectrum of disability and permits broader participation with fewer in-person assessments.
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Registered trials
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