Evidence map›Paper›PMID 33236955›Full record

ArticleMolecular biology of the cell2021

Unconventional endocytosis and trafficking of transferrin receptor induced by iron.

Elena Gammella, Irene Schiano Lomoriello, Alexia Conte, Stefano Freddi, Alessandra Alberghini, Maura Poli, Sara Sigismund, Gaetano Cairo, Stefania Recalcati

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
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  3. Oxidative Stress andInternational journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Elena GammellaDepartment of Biomedical Sciences for Health, University of Milan, 20133 Milan, Italy.
Irene Schiano LomorielloIEO, Istituto Europeo di Oncologia IRCCS, 20141 Milan, Italy.
Alexia ConteIEO, Istituto Europeo di Oncologia IRCCS, 20141 Milan, Italy.
Stefano FreddiIEO, Istituto Europeo di Oncologia IRCCS, 20141 Milan, Italy.
Alessandra AlberghiniDepartment of Biomedical Sciences for Health, University of Milan, 20133 Milan, Italy.
Maura PoliDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Sara SigismundIEO, Istituto Europeo di Oncologia IRCCS, 20141 Milan, Italy.
Gaetano CairoDepartment of Biomedical Sciences for Health, University of Milan, 20133 Milan, Italy.
Stefania RecalcatiDepartment of Biomedical Sciences for Health, University of Milan, 20133 Milan, Italy.
University of Milan · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITUniversity of Brescia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The posttranslational regulation of transferrin receptor (TfR1) is largely unknown. We investigated whether iron availability affects TfR1 endocytic cycle and protein stability in HepG2 hepatoma cells exposed to ferric ammonium citrate (FAC). NH

Indexed as

EndocytosisAdaptor Protein Complex 2Adaptor Protein Complex mu SubunitsApoferritinsDown-RegulationHeLa CellsHep G2 CellsHumansIronLysosomesProtein TransportReceptors, TransferrinTransferrinAdaptor Protein Complex 2adaptor protein complex 2, mu 1 subunitAdaptor Protein Complex mu SubunitsApoferritinsIronReceptors, TransferrinTransferrin

Identifiers

PMID33236955
PMCPMC8120689
OpenAlexW3109596984

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.