Evidence map›Paper›PMID 33236920›Full record

ReviewAmerican journal of physiology. Endocrinology and metabolism2021

COVID-19 endocrinopathy with hindsight from SARS.

Narasimhan Kothandaraman, Anantharaj Rengaraj, Bo Xue, Wen Shan Yew, S Sendhil Velan, Neerja Karnani, Melvin Khee Shing Leow

Open access · greenAbstract readReview
In one paragraph

Review in American journal of physiology. Endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Inflammatory indices as early predictors of mortality in mucormycosis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  3. A Comparative Analysis of COVID-19-Associated and Non-COVID-19-Associated MucormycosisEndocrine, metabolic & immune disorders drug targets · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Viruses and Endocrine Diseases.Microorganisms · 2023
    Review
  11. Article
  12. Review
  13. Mucormycosis in 2023: an update on pathogenesis and management.Frontiers in cellular and infection microbiology · 2023
    Review
  14. Article
  15. Review
  16. Rhino-Orbito-Cerebral Mucormycosis During the Second Wave of Covid-19: The Indian Scenario.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022
    Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Narasimhan KothandaramanSingapore Institute for Clinical Sciences, Brenner Centre for Molecular Medicine, Agency for Science, Technology and Research (A*STAR), Singapore.
Anantharaj RengarajLaboratory of Molecular Imaging, Singapore Bioimaging Consortium, A*STAR, Singapore.
Bo XueDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Wen Shan YewDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
S Sendhil VelanSingapore Institute for Clinical Sciences, Brenner Centre for Molecular Medicine, Agency for Science, Technology and Research (A*STAR), Singapore.
Neerja KarnaniSingapore Institute for Clinical Sciences, Brenner Centre for Molecular Medicine, Agency for Science, Technology and Research (A*STAR), Singapore.
Melvin Khee Shing LeowSingapore Institute for Clinical Sciences, Brenner Centre for Molecular Medicine, Agency for Science, Technology and Research (A*STAR), Singapore.
Singapore Institute for Clinical Sciences · SGNational University of Singapore · SGAgency for Science, Technology and Research · SG

Funding

Singapore Institute for Clinical Sciences (SICS) NA
6 · The paper itself

Abstract

The current COVID-19 pandemic is probably the worst the world has ever faced since the start of the new millennium. Although the respiratory system is the most prominent target of SARS-CoV-2 (the contagion of COVID-19), extrapulmonary involvement are emerging as important contributors of its morbidity and lethality. This article summarizes the impact of SARS-CoV and SARS-CoV-2 on the endocrine system to facilitate our understanding of the nature of coronavirus-associated endocrinopathy. Although new data are rapidly accumulating on this novel infection, many of the endocrine manifestations of COVID-19 remain incompletely elucidated. We, hereby, summarize various endocrine dysfunctions including coronavirus-induced new onset diabetes mellitus, hypocortisolism, thyroid hormone, and reproductive system aberrations so that clinicians armed with such insights can potentially benefit patients with COVID-19 at the bedside.

Indexed as

Angiotensin-Converting Enzyme 2COVID-19Endocrine System DiseasesHumansNeuropilin-1PandemicsSARS-CoV-2Serine EndopeptidasesSevere Acute Respiratory SyndromeSevere acute respiratory syndrome-related coronavirusACE2 protein, humanAngiotensin-Converting Enzyme 2Neuropilin-1Serine EndopeptidasesTMPRSS2 protein, humanCOVID-19endocrine systemSARSSARS-CoV-2virus

Identifiers

PMID33236920
PMCPMC7816429
OpenAlexW3109096439

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.