Evidence map›Paper›PMID 33236888›Full record

ArticleACS nano2021

Single Cell Forces after Electroporation.

Philip M Graybill, Aniket Jana, Rakesh K Kapania, Amrinder S Nain, Rafael V Davalos

Abstract read
In one paragraph

Article in ACS nano, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. [Coupling characteristics of cellular electroporation and electrodeformation based on dynamic Young's modulus: influence of membrane thickness].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026
    Article
  3. Article
  4. Article
  5. Deep learning reveals how cells pull, buckle, and navigate fibrous environments.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Cancer cell dynamics on silica fibers.Scientific reports · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Sculpting Rupture-Free Nuclear Shapes in Fibrous Environments.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Article
  16. Article
  17. Review
  18. HumanFrontiers in physiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Philip M GraybillDepartment of Mechanical Engineering, Virginia Tech, Blacksburg, Virginia 24061, United States.ORCID 0000-0002-2057-7478
Aniket JanaDepartment of Mechanical Engineering, Virginia Tech, Blacksburg, Virginia 24061, United States.ORCID 0000-0003-2830-8210
Rakesh K KapaniaDepartment of Aerospace and Ocean Engineering, Virginia Tech, Blacksburg, Virginia 24061, United States.
Amrinder S NainDepartment of Mechanical Engineering, Virginia Tech, Blacksburg, Virginia 24061, United States.ORCID 0000-0002-9757-2341
Rafael V DavalosDepartment of Mechanical Engineering, Virginia Tech, Blacksburg, Virginia 24061, United States.ORCID 0000-0003-1503-9509

Funding

Sub-component for Institution # 16-01848 Novel moleculary targeted therapy of GBMP01CA207206 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DEBINSKI, WALDEMAR · 2017 to 2021
$9.0M
NCI NIH HHS P01 CA207206
6 · The paper itself

Abstract

Exogenous high-voltage pulses increase cell membrane permeability through a phenomenon known as electroporation. This process may also disrupt the cell cytoskeleton causing changes in cell contractility; however, the contractile signature of cell force after electroporation remains unknown. Here, single-cell forces post-electroporation are measured using suspended extracellular matrix-mimicking nanofibers that act as force sensors. Ten, 100 μs pulses are delivered at three voltage magnitudes (500, 1000, and 1500 V) and two directions (parallel and perpendicular to cell orientation), exposing glioblastoma cells to electric fields between 441 V cm

Indexed as

ActinsElectroporationCell MembraneCell Membrane PermeabilityCell SurvivalCytoskeletonActinsactincytoskeletonelectroporationforcesmechanobiologynanofiberspulsed electric fields

Identifiers

PMID33236888
PMCPMC10949415

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.