ArticleNMR in biomedicine2021
Contribution of macromolecules to brain
Article in NMR in biomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
78 citing papers in PubMed.
- Double DANTE-PRESS: Development of a 1H-MRS Multifrequency-Selective Sequence for Simultaneous In Vivo Quantification of Glutathione and Glutamate at 7 Tesla.NMR in biomedicine · 2026Article
- Age-dependent macromolecule signals in the human motor cortex and thalamus: implications for metabolites quantification at 7 T.Magma (New York, N.Y.) · 2026Article
- Effect of Water Suppression and Metabolite Cycling on Quantification ofMagnetic resonance in medicine · 2026Article
- Mastering preclinical proton and deuterium-based fast MRSI in the brain: from setup to execution.Magma (New York, N.Y.) · 2026Review
- MRS4Brain: a software for preclinical proton and deuterium-based MR spectroscopic imaging data.Magma (New York, N.Y.) · 2026Article
- An imaging biomarker to detect non-glucogenic shift in brain energy metabolism in Alzheimer's disease.Journal of translational medicine · 2026Article
- In vivo brain macromolecules in schizophrenia spectrum disorders.Schizophrenia (Heidelberg, Germany) · 2026Article
- Development and in vivo proof-of-concept of delayed alternating nutation tailored excitation point resolved spectroscopy (dante-press): a frequency-selective single voxel spectroscopy sequence applied to in vivo measurements of naa and glu at 7.0 T.Magma (New York, N.Y.) · 2026Article
- Towards harmonized spectral quantification in MRSI: comparative analysis of backward-linear-predicted and originalMagma (New York, N.Y.) · 2026Article
- Differentiating Creatine and Phosphocreatine In Vivo Using 3 TMagnetic resonance in medicine · 2026Article
- Neuroimaging insights from Wistar-Kyoto rats under chronic mild stress: morphological and metabolic brain correlates of treatment-resistant depression.Scientific reports · 2026Article
- Simultaneous in vivo detection of spectrally resolved glutamate, glutamine, and glutathione at 3 T with NAA-aspartyl editing and echo-time optimization.Magnetic resonance in medicine · 2026Article
- In Vivo Glx Measurements From GABA-Edited HERMES at 3 T Are Not Consistent With Those From Short-TE PRESS Across Scanners, Brain Regions, Diagnostic and Age Groups.NMR in biomedicine · 2026Article
- Clinical application ofFrontiers in neuroscience · 2026Article
- A data-driven algorithm to determineMagnetic resonance in medicine · 2026Article
- MRS-Sim: Open-Source Framework for Simulating In Vivo-Like Magnetic Resonance Spectra.NMR in biomedicine · 2025Article
- In vivo GABA detection by single-pulse editing with one shot.Magnetic resonance in medicine · 2025Article
- Rosette Spectroscopic Imaging for Whole-Brain Slab Metabolite Mapping at 7T: Acceleration Potential and Reproducibility.Human brain mapping · 2025Article
- Joint learning of nonlinear representation and projection for fast constrained MRSI reconstruction.Magnetic resonance in medicine · 2025Article
- Simultaneous Concentration and TNMR in biomedicine · 2025Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors.
Funding
Abstract
Proton MR spectra of the brain, especially those measured at short and intermediate echo times, contain signals from mobile macromolecules (MM). A description of the main MM is provided in this consensus paper. These broad peaks of MM underlie the narrower peaks of metabolites and often complicate their quantification but they also may have potential importance as biomarkers in specific diseases. Thus, separation of broad MM signals from low molecular weight metabolites enables accurate determination of metabolite concentrations and is of primary interest in many studies. Other studies attempt to understand the origin of the MM spectrum, to decompose it into individual spectral regions or peaks and to use the components of the MM spectrum as markers of various physiological or pathological conditions in biomedical research or clinical practice. The aim of this consensus paper is to provide an overview and some recommendations on how to handle the MM signals in different types of studies together with a list of open issues in the field, which are all summarized at the end of the paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.