Evidence map›Paper›PMID 33236800›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2021

Dipyrrinato-Iridium(III) Complexes for Application in Photodynamic Therapy and Antimicrobial Photodynamic Inactivation.

Benjamin F Hohlfeld, Burkhard Gitter, Christopher J Kingsbury, Keith J Flanagan, Dorika Steen, Gerhard D Wieland, Nora Kulak, Mathias O Senge, Arno Wiehe

Abstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Recent Advances in Metal Complexes for Antimicrobial Photodynamic Therapy.Chembiochem : a European journal of chemical biology · 2023
    Review
  9. Article
  10. Metals to combat antimicrobial resistance.Nature reviews. Chemistry · 2023
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Crystal structures of 4-bromo-2-formyl-1-tosyl-1Acta crystallographica. Section E, Crystallographic communications · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Benjamin F HohlfeldInstitut für Chemie u. Biochemie, Freie Universität Berlin, Takustr. 3, 14195, Berlin, Germany.ORCID http://orcid.org/0000-0001-8508-2460
Burkhard Gitterbiolitec research GmbH, Otto-Schott-Str. 15, 07745, Jena, Germany.
Christopher J KingsburyMedicinal Chemistry, Trinity Translational Medicine Institute, Trinity Centre for Health Sciences, Trinity College Dublin, The University of Dublin, St James's Hospital, Dublin, 8, Ireland.ORCID http://orcid.org/0000-0002-4694-5566
Keith J FlanaganMedicinal Chemistry, Trinity Translational Medicine Institute, Trinity Centre for Health Sciences, Trinity College Dublin, The University of Dublin, St James's Hospital, Dublin, 8, Ireland.ORCID http://orcid.org/0000-0003-1656-3177
Dorika Steenbiolitec research GmbH, Otto-Schott-Str. 15, 07745, Jena, Germany.
Gerhard D Wielandbiolitec research GmbH, Otto-Schott-Str. 15, 07745, Jena, Germany.ORCID http://orcid.org/0000-0003-1034-4897
Nora KulakInstitut für Chemie u. Biochemie, Freie Universität Berlin, Takustr. 3, 14195, Berlin, Germany.ORCID http://orcid.org/0000-0002-8347-4046
Mathias O SengeMedicinal Chemistry, Trinity Translational Medicine Institute, Trinity Centre for Health Sciences, Trinity College Dublin, The University of Dublin, St James's Hospital, Dublin, 8, Ireland.ORCID http://orcid.org/0000-0002-7467-1654
Arno WieheInstitut für Chemie u. Biochemie, Freie Universität Berlin, Takustr. 3, 14195, Berlin, Germany.ORCID http://orcid.org/0000-0002-6289-7672

Funding

Bundesministerium für Bildung und Forschung 03ZZ0927BH2020 Marie Skłodowska-Curie Actions 764837Science Foundation Ireland IvP 13/IA/1894Technische Universität München Institute for Advanced Study - Hans Fischer Senior Fellowship
6 · The paper itself

Abstract

The generation of bio-targetable photosensitizers is of utmost importance to the emerging field of photodynamic therapy and antimicrobial (photo-)therapy. A synthetic strategy is presented in which chelating dipyrrin moieties are used to enhance the known photoactivity of iridium(III) metal complexes. Formed complexes can thus be functionalized in a facile manner with a range of targeting groups at their chemically active reaction sites. Dipyrrins with N- and O-substituents afforded (dipy)iridium(III) complexes via complexation with the respective Cp*-iridium(III) and ppy-iridium(III) precursors (dipy=dipyrrinato, Cp*=pentamethyl-η

Indexed as

Anti-Infective AgentsCoordination ComplexesPhotochemotherapyIridiumPhotosensitizing AgentsAnti-Infective AgentsCoordination ComplexesIridiumPhotosensitizing Agentsantimicrobial photodynamic inactivation(dipyrrinato)iridium(III) complexesdipyrrinsglycosylationphotodynamic therapy

Identifiers

PMID33236800
PMCPMC8248005

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.