ArticleJournal of the American Geriatrics Society2021
Beyond the Health Deficit Count: Examining Deficit Patterns in a Deficit-Accumulation Frailty Index.
Article in Journal of the American Geriatrics Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Antiretroviral Therapy Changes for Medicare Beneficiaries With HIV Transitioning to Long-Term Care.JAMA network open · 2025Article
- Frailty in Cardiac Surgery-Assessment Tools, Impact on Outcomes, and Optimisation Strategies: A Narrative Review.Journal of cardiovascular development and disease · 2025Review
- Impact of Pre-Existing Frailty on Cardiotoxicity Among Breast Cancer Patients Receiving Adjuvant Therapy.JACC. CardioOncology · 2025Article
- Geriatric Conditions Associated with Nonadherence to Antiretroviral Therapy Among Older People with HIV: The Importance of Frailty.AIDS patient care and STDs · 2022Article
- Frailty and Differences in Self-Reported Sexual Functioning Among Older Females and Males in National Social life, Health and Aging Project.Journal of aging and healthArticle
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Authors and funding
5 authors.
Funding
Abstract
BACKGROUND/
objectivesExploring deficit patterns among frail people may reveal subgroups of different prognostic importance.
designAnalysis of National Health and Aging Trends Study.
settingCommunity.
participantsCommunity dwelling older adults with mild to moderate frailty (deficit-accumulation frailty index (FI) of 0.25-0.40) (n = 1821). MEASUREMENTS: Latent class analysis identified distinct clinical subgroups based on comorbidity (range: 0-10), National Health and Aging Trends Study dementia classification, and short physical performance battery (SPPB) (range: 0-12). Survival analyses compared 5-year mortality by subgroups.
resultsThree latent classes existed: Class 1 (n = 831, mean FI = 0.30) had 2.7% probable dementia, high comorbidities (mean = 3.6), and low physical impairment (SPPB mean = 9.9); Class 2 (n = 734, mean FI = 0.32) had 6.9% probable dementia, low comorbidities (mean = 2.8), and moderate physical impairment (SPPB mean = 6.2); Class 3 (n = 256, mean FI = 0.34) had 20.7% probable dementia, low comorbidities (mean = 2.4), and high physical impairment (SPPB mean = 2.0). Compared to Class 1, Classes 2 and 3 experienced higher 5-year mortality (C2: 1.28 (95% confidence intervals (CI) = 1.00-1.62); C3: 1.87 (95% CI = 1.29-2.73)).
conclusionDeficit patterns among the mild-to-moderately frail provide additional prognostic information and highlight opportunities for preventive interventions.
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