Evidence map›Paper›PMID 33236247›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2021

Different functional connectivity modes of the right fronto-insular cortex in akinetic-rigid and tremor-dominant Parkinson's disease.

Juan Wang, Yalian Shen, Juan Peng, Anran Wang, Xiaolin Wu, Xiaocui Chen, Jinjin Liu, Min Wei, Dezhi Zou, Yu Han and 1 more

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Juan WangDepartment of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
Yalian ShenDepartment of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
Juan PengDepartment of Radiology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
Anran WangDepartment of Radiology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
Xiaolin WuDepartment of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
Xiaocui ChenDepartment of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
Jinjin LiuDepartment of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
Min WeiDepartment of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
Dezhi ZouDepartment of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
Yu HanDepartment of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
Oumei ChengDepartment of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China. chengoumei@cqmu.edu.cn.ORCID http://orcid.org/0000-0002-1889-6541
The Affiliated Yongchuan Hospital of Chongqing Medical University · CN

Funding

Natural Science Foundation of China No.81871002, 81471334, 81100981
6 · The paper itself

Abstract

backgroundPatients with akinetic-rigid Parkinson's disease (AR-PD) are more prone to cognitive decline and depressive symptoms than tremor-dominant PD (TD-PD) patients. The right fronto-insular cortex (rFIC), as a key node of salience network, plays a critical role in the switching between central executive network and default mode network. In this study, we explored the functional connectivity mode of rFIC with triple-brain networks, namely default mode network, salience network, and central executive network, in two motor subtypes of PD.

methodsWe recruited 44 PD patients (including the TD-PD group and AR-PD group) and 18 age-matched healthy controls (HCs). We performed functional connectivity (FC) analysis of resting-state functional MRI.

resultsCompared with TD-PD, decreased FC were found in the right insular cortex and bilateral anterior cingulate gyrus in AR-PD. Compared with HCs, decreased FC in the bilateral insula, the anterior cingulate gyrus, the precentral gyrus, and the right medial frontal gyrus were found; therein, the FC value of rFIC-precentral gyrus was positively correlated with the Unified Parkinson's Disease Rating Scale-II score in AR-PD (p = 0.0482, r = 0.4162). While TD-PD showed decreased FC in the left insula as well as bilateral anterior cingulate gyrus when compared with HCs, and the FC value of the rFIC-left insula was positively correlated with its Hamilton Depression Rating Scale score (p = 0.02, r = 0.50).

conclusionThe functional connectivity mode of rFIC in AR-PD differed from that in TD-PD. The decreased rFIC FC with the other nodes of salience network might be a potential indicator for AR-PD patients prone to develop cognitive decline and depressive symptoms.

Indexed as

Parkinson DiseaseBrain MappingCerebral CortexHumansMagnetic Resonance ImagingTremorAkinetic-rigid Parkinson’s diseaseCognitive deficitDepressive symptomFunctional connectivityRight fronto-insular cortexSalience networkTremor-dominant Parkinson's disease

Identifiers

PMID33236247
OpenAlexW3109107013

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.